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Metabolic network visualization using constraint planar graph drawing algorithm

机译:使用约束平面图绘制算法的代谢网络可视化

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A metabolic network is a set of interconnected metabolic pathways (subnetworks). Until recently, metabolic studies were dedicated to a single pathway, but current researches now consider the entire network. As matter stands, existing visualization tools cannot be used to undertake these global studies since they have been designed to probe metabolic pathways. For the purpose of making it feasible, this paper presents a graph drawing algorithm for the whole metabolic network. Our collaboration with biologists led us to introduce drawing constraints which take into account the decomposition of the network into metabolic pathways as well as biochemical textbook drawing conventions. These constraints raise numerous graph drawing problems which are solved by first recursively decomposing the network then applying suitable graph drawing algorithms. Finally, we present an application that illustrates the advantage of this representation when visualizing groups of reactions which span several metabolic pathways.
机译:代谢网络是一组相互连接的代谢途径(子网络)。直到最近,代谢研究还专门针对单一途径,但是目前的研究现在考虑了整个网络。就目前而言,现有的可视化工具无法用于进行这些全局研究,因为它们已被设计为探测代谢途径。为了使其可行,本文提出了一种用于整个代谢网络的图形绘制算法。我们与生物学家的合作使我们引入了绘图限制,其中考虑了网络分解为代谢途径以及生化教科书绘图惯例的问题。这些约束提出了许多图形绘制问题,这些问题首先通过递归分解网络然后应用适当的图形绘制算法来解决。最后,我们提出了一个应用程序,该应用程序在可视化跨越几种代谢途径的反应组时说明了这种表示法的优势。

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