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首页> 外文会议>国际营养科学联盟第八届临床营养学大会暨第五届亚太临床营养学会大会 >Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review
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Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review

机译：左旋肉碱和/或左旋乙酰肉碱在男性不育症营养治疗中的作用：系统评价

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The aim of this systematic review was to quantify the efficacy of L-carnitine (LC) and/or L-acetyl-carnitine (LAC) in nutrition treatment for male infertility according to present clinical evidence. Biomedical databases were searched to collect related clinical trials and nine relevant randomized controlled trials (RCTs) were included.The quality of the RCTs was assessed based on their performance in randomization, blinding, and allocation concealment. The meta-analysis compared LC and/or LAC therapy to placebo treatment found significant improvement in pregnancy rate (OR =4.10, 95% CI (2.08, 8.08), p＜0.0001), total sperm motility (WMD =7.43,95% CI (1.72, 13.14), p =0.04, forward sperm motility (WMD =11.83, 95% CI (0.49, 23.16), p =0.04) and atypical sperm cell (WMD =-5.72, 95% CI (-7.89, -3.56), p＜0.00001). However, no significant difference was found in the sperm concentration (WMD =5.69, 95% CI (-4.47, 15.84), p =0.27) and semen volume (WMD =0.28, 95% CI (-0.02, 0.58), p =0.07). In conclusion, the administration of LC and/or LAC may be effective in improving pregnancy rate and sperm kinetic features in patients affected by male infertility. However, the exact efficacy of carnitines on male infertility needs to be confirmed by further investigations.
机译：本系统综述的目的是根据目前的临床证据，对L-肉碱（LC）和/或L-乙酰肉碱（LAC）在男性不育症营养治疗中的疗效进行量化。搜索生物医学数据库以收集相关的临床试验，包括9项相关的随机对照试验（RCT）.RCT的质量根据其在随机化，盲法和分配隐蔽性方面的表现进行评估。荟萃分析比较了LC和/或LAC治疗与安慰剂治疗之间的关系，发现妊娠率（OR = 4.10，95％CI（2.08，8.08），p ＜0.0001），总精子活力（WMD = 7.43,95％CI）有显着改善。 （1.72，13.14），p = 0.04，向前精子运动（WMD = 11.83，95％CI（0.49，23.16），p = 0.04）和非典型精子细胞（WMD = -5.72，95％CI（-7.89，-3.56） ），p ＜0.00001）。然而，精子浓度（WMD = 5.69，95％CI（-4.47，15.84），p = 0.27）和精液量（WMD = 0.28，95％CI（-）均无显着差异。 0.02，0.58），p = 0.07）。总之，LC和/或LAC的使用可能对改善男性不育症患者的妊娠率和精子动力学特征有效，但是肉碱对男性不育症的确切疗效需要有待进一步调查确认。

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