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Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis

机译：选择性雌激素受体调节剂对雄性不孕症治疗的影响：系统评价和荟萃分析

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Background: Selective estrogen receptor modulators (SERMs) represent a poorly investigated class of drugs for the treatment of male infertility. The aim of this study was to assess the effects of SERMs on conventional sperm parameters, serum gonadotropin and testosterone levels, and pregnancy rate in patients with idiopathic infertility. Methods: The authors performed a comprehensive systematic review with meta-analysis of all available controlled and not-controlled studies of the literature reporting sperm conventional parameters, gonadotropin and testosterone levels, and/or the pregnancy rate following SERM administration in normogonadotropic patients with idiopathic oligozoospermia. Results: From the 418 papers retrieved, 16 controlled and not-controlled trials were lastly included. SERM administration increased significantly sperm concentration, total sperm count, and serum luteinizing hormone, follicle-stimulating hormone, and total testosterone levels compared with baseline values. In contrast, SERMs did not have any significant effect on sperm concentration and progressive and total motility, but improved total sperm count, sperm morphology, and increased the pregnancy rate compared to the control group, which included studies done with placebo or other treatments. Conclusions: The results of this meta-analysis suggest that SERMs may be effective in the treatment of infertile patients with idiopathic infertility. However, the paucity of data does not allow to draw a definitive conclusion.
机译：背景：选择性雌激素受体调节剂（SERMS）代表了用于治疗男性不孕症的较差的药物类药物。本研究的目的是评估SERMS对常规精子参数，血清促性腺激素和睾酮水平的影响，以及特发性不孕症患者的妊娠率。方法：作者对文献报告精子常规参数，促性腺激素和睾丸激素水平的所有可用受控和未受控研究进行了全面的系统审查，以及在正常发作性少血症患者的常规同胞凋亡患者中SERM施用后的妊娠率。结果：从检索到的418篇论文，最后包括16项控制和不受控制的试验。与基线值相比，SERM给药显着增加了精子浓度，总精子计数和血清叶英激素，卵泡刺激激素和总睾酮水平。相比之下，SERMS对精子浓度和进步和总挥发性的任何显着影响，但是与对照组相比，改善了总精子数，精子形态，并增加了妊娠率，其中包括用安慰剂或其他治疗方法进行研究。结论：该荟萃分析的结果表明，Serms可有效治疗特发性不孕症的不孕症患者。但是，数据的缺乏不允许绘制明确的结论。

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