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首页> 外文会议>The 11th World Multi-Conference on Systemics, Cybernetics and Informatics(WMSCI 2007) Jointly with the 13th International Conference on Information Systems Analysis and Synthesis(ISAS 2007) >A comparison of genome sequences among the H5N1 strains of Hong Kong,Thailand, Vietnam and China
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A comparison of genome sequences among the H5N1 strains of Hong Kong,Thailand, Vietnam and China

机译：香港，泰国，越南和中国的H5N1毒株基因组序列比较

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The avian flu virus caused infection and epidemic not only in poultry, but also in human or other mammals breaking the species barriers. In the analyses, a total of 39 genome sequences of the H5N1 strains isolated in Hong Kong, Thailand, Vietnam and China were compared the evolution and characterized according to geographic distribution. HA, NA and M2 gene sequences of H5N1 isolates were selected by using Editseq program of LaserGene. The differences of nucleotide and amino acid sequences were analyzed with Clustal X and DNAMAN. The human-infected H5N1 strains reported in 2004 in Thailand, Vietnam and 1997 in Hong Kong contained the same amino acid sequences at the cleavage sites in the HA protein and shared the saihe receptor-binding sites. A deletion of 20 amino acids in the NA protein and one addition glycosylaton site in the HA protein were found in the H5N1 infected human strains in Thailand and Vietnam. Several certain amino acids of M2 protein mutated in that led some of H5N1 viruses amantadine-resistant in Thailand and Vietnam. There were three nucleotides deletions at the site adjacent to the cleavage sites in the HA protein observed in nine poultry isolates of China compared with other 18 poultry isolates of China and 14 human isolates of Hong Kong, Thailand, Vietnam. A sequence of five-six amino acids (RRRK K/R R) in the flank of 5' end of the cleavage sites in the HA protein was observed from all H5N1 strains in China, Hong Kong, Thailand and Vietnam.
机译：禽流感病毒不仅在禽类中引起感染和流行，而且在人类或其他哺乳动物中也打破了物种壁垒。在分析中，比较了香港，泰国，越南和中国分离出的H5N1菌株的39个基因组序列的进化，并根据地理分布进行了表征。使用LaserGene的Editseq程序选择H5N1分离株的HA，NA和M2基因序列。用Clustal X和DNAMAN分析核苷酸和氨基酸序列的差异。 2004年泰国，越南和香港1997年报道的人类感染H5N1菌株在HA蛋白的切割位点包含相同的氨基酸序列，并共有saihe受体结合位点。在泰国和越南感染H5N1的人类菌株中，发现NA蛋白中20个氨基酸的缺失和HA蛋白中一个糖基化位点的缺失。在泰国和越南，M2蛋白的某些特定氨基酸突变导致某些H5N1病毒对金刚烷胺具有抗性。与中国的其他18家禽分离株和香港，泰国，越南的14种人分离株相比，在中国的9种家禽分离株中观察到的HA蛋白裂解位点附近的核苷酸缺失了3个核苷酸。在中国，香港，泰国和越南的所有H5N1菌株中，均观察到HA蛋白裂解位点5'侧翼的5-6个氨基酸序列（RRRK K / R R）。

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