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首页> 外文会议>Trends in Radiopharmaceuticals(ISTR-2005) >Use of stannous fluoride as reducer agent for 99mTc-labelling ciprofloxacin.Pharmacokinetics and biodistribution in animals
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Use of stannous fluoride as reducer agent for 99mTc-labelling ciprofloxacin.Pharmacokinetics and biodistribution in animals

机译：氟化亚锡作为还原剂用于99mTc标记的环丙沙星的动物药代动力学和生物分布

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The aim of the present work was to develop a simple and reproducible method for preparingciprofloxacin kit employing stannous fluoride (SnF2) as a reducing agent for 99mTc. Materials andmethods: Several molars relationships of ciprofloxacin: SnF2 were assessed. Biokinetic studies in healthyrats and rats bearing an abscess produced by Staphilococcus aureus and Echerichia Coli were performed.Results: The labelling yield was >95% for more than 6 hours. The abscess/counterlateral thigh ratio rose upto 4.21±1.13 and 5.00±0.29 at 20h for Escherichia coli and Staphylococcus aureus, respectively. Markedaccumulation kidneys and bowels were observed. The radiopharmaceutical showed a fast plasma clearance.41±1% of the injected dose excreted via urinary tract. Conclusions: Developed method for 99mTc-labellingof ciprofloxacin using stannous fluoride as reducing agent resulted a simple procedure, with a satisfactorystability. Ciprofloxacin labelled by this approach should be suitable for scintigraphic imaging of infections.
机译：本工作的目的是开发一种简单且可重现的制备方法 环丙沙星试剂盒，采用氟化亚锡（SnF2）作为99mTc的还原剂。材料和 方法：评估环丙沙星：SnF2的几种摩尔关系。健康中的生物动力学研究 进行大鼠和带有金黄色葡萄球菌和大肠杆菌的脓肿的大鼠。 结果：超过6小时的标记收率> 95％。脓肿/大腿外侧比上升 大肠杆菌和金黄色葡萄球菌在20h分别达到4.21±1.13和5.00±0.29。已标记 观察到肾脏和肠积聚。放射性药物显示出快速的血浆清除率。 注射剂量的41±1％通过尿道排泄。结论：99mTc标记的开发方法 氟化亚锡作为还原剂制备环丙沙星的操作简单，效果令人满意 稳定。用这种方法标记的环丙沙星应适用于感染的闪烁显像。

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