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首页> 外文会议>Trends in Radiopharmaceuticals(ISTR-2005) >188W/188Re GENERATOR – INVESTIGATION OF LONG TERM STABILITY
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188W/188Re GENERATOR – INVESTIGATION OF LONG TERM STABILITY

机译：188W / 188Re发电机–长期稳定性研究

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The rhenium-188 (T1/2 = 16,98 h) is a beta-gamma emitting radionuclide (average energy of β-particles - 764 keV) suitable for therapeutical application. The gamma emission of 188Re (155 keV) allowsevaluation of biodistribution of 188Re labelled radiopharmaceuticals and is useful in radiation dosimetry study.188Re is produced in decay of 188W followed by the chromatographic separation. The production of 188Re at thecentralized laboratory needs handling of large amounts of activity to overcome the loss of activity during isotopeproduction and transportation to the end user. The aim of this work was to develop a 188W/188Re portablegenerator using high specific activity 188W and the available design of generator column. In this paper we presentresults of the long term stability study of 188W/188Re generator developed in our laboratory. The generatorcolumn containing alumina was first activated by washing with a set of solutions. The radioactivities of about 5.5GBq of 188W (195 GBq/g W) in the form of tungstenic acid were loaded on the column (flow 0.1 ml/min). After188W deposition the alumina column was washed with 0.9% NaCl solution (pH = 5.0 – 6.0). Each of themanufactured generators was eluted 2-3 times per week over the period of up to 9 months. The elution yield, theradionuclidic purity, the radiochemical purity and chemical purity of the eluted 188Re-perrhenate solution weretested in each of the elutions. Bacterial endotoxines test and sterility test were performed at the production dateand at 2 months intervals. The results of our study show that the generators can be eluted with high, over 75%elution yield. No changes in quality of eluates were observed over the time of their examination, proving theirstable performance.
机译：188 188（T1 / 2 = 16,98 h）是发射β-γ的放射性核素（β- 颗粒-764 keV）适合治疗应用。 188Re（155 keV）的伽马发射允许 188Re标记放射性药物的生物分布评估，可用于辐射剂量学研究。 188Re衰变后产生188W，然后进行色谱分离。 188Re的生产 集中式实验室需要处理大量活动，以克服同位素过程中活动的损失 生产和运输到最终用户。这项工作的目的是开发188W / 188Re便携式 发生器使用高比活度188W和可用的发生器色谱柱设计。在本文中，我们介绍 我们实验室开发的188W / 188Re发电机长期稳定性研究的结果。发电机 首先通过用一组溶液洗涤来活化包含氧化铝的柱。放射性约为5.5 以钨酸形式的188W GBq（195 GBq / g W）加载到色谱柱上（流速0.1 ml / min）。后 188W沉积氧化铝柱用0.9％NaCl溶液（pH = 5.0 – 6.0）洗涤。每个 制造的发电机在长达9个月的时间内每周要洗2-3次。洗脱量 洗脱的188Re-高r酸盐溶液的放射性核素纯度，放射化学纯度和化学纯度分别为 在每种洗脱液中均进行了测试。生产日期进行了细菌内毒素测试和无菌测试 并且每2个月间隔一次。我们的研究结果表明，发生器可以被高洗脱，超过75％ 洗脱产率。在检查期间未观察到洗脱液质量的变化，证明了洗脱液的质量 性能稳定。

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