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首页> 外文会议>Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets >Strongly Reduced Number of Parvalbumin-Immunoreactive Projection Neurons in the Mammillary Bodies in Schizophrenia
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Strongly Reduced Number of Parvalbumin-Immunoreactive Projection Neurons in the Mammillary Bodies in Schizophrenia

机译：精神分裂症乳头体内小白蛋白-免疫反应性投射神经元的数量大大减少

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The mammillary bodies (MB) are important relay nuclei within limbic and extralimbic connections. They are known to play im portant roles in memory formation and are affected in alcoholism and vitamin B1 deficiency. Their strategic position linking temporo-limbic to cortico-thalamic brain structures make the MB a candidate brain structure for alterations in schizophrenia. We studied 15 postmortem brains of schizophrenics and 15 matched control brains. Brain sec tions were stained either with Heidenhain-Woelcke, glutamic acid decarboxylase (GAD), calretinin, or parvalbumin. We determined the volumes of the MB and performed cell countings using stereological principles and a computerized image analysis system. The volumes of MB do not differ between schizophrenics and controls. However, in schizophrenia the number of neurons as well as the resulting neu ronal densities was significantly reduced on both sides (on left side by 38.9%, on right side by 22%). No changes were seen in the num ber of GAD-expressing or calretinin-containing neurons, whereas the number of parvalbumin-immunoreactive MB neurons was reduced by more than 50% in schizophrenia. This cell loss (as a result of develop mental malformation and/or neurodegeneration) points to a prominent involvement of the MB in the pathomorphology of schizophre nia. Parvalbumin-immunoreactive GABAergic interneurons have been reported to be diminished in schizophrenia. However, in the MB parval bumin labels a subpopulation of glutamate/aspartate-containing neurons projecting mainly to the anterior thalamus. Thus, our data provide new evidence for impaired limbic circuits in schizophrenia.
机译：乳头体（MB）是边缘和上缘连接内的重要中继核。众所周知，它们在记忆形成中起重要作用，并且会在酒精中毒和维生素B1缺乏症中受到影响。它们的战略地位将颞下肢与皮质-丘脑的大脑结构联系在一起，使MB成为精神分裂症改变的候选大脑结构。我们研究了精神分裂症的15个死后大脑和15个匹配的对照大脑。用Heidenhain-Woelcke，谷氨酸脱羧酶（GAD），钙网蛋白或小白蛋白对脑部染色。我们确定了MB的体积，并使用立体学原理和计算机图像分析系统进行了细胞计数。精神分裂症患者和对照组之间的MB量没有差异。但是，在精神分裂症中，神经元的数量以及所产生的神经元密度在两侧均显着减少（左侧减少38.9％，右侧减少22％）。在精神分裂症中，表达GAD或包含钙网蛋白的神经元数量没有变化，而小白蛋白免疫反应性MB神经元的数量减少了50％以上。这种细胞丢失（由于发展为精神畸形和/或神经退行性变）表明MB明显参与了精神分裂症的病理形态。据报道，精神分裂症患者的小白蛋白免疫反应性GABA能性中枢神经元减少。然而，在MB卵清蛋白标记中，主要向丘脑前部突出的谷氨酸/天冬氨酸神经元亚群。因此，我们的数据为精神分裂症的边缘回路受损提供了新的证据。

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