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首页> 外文会议>7th Asian-Pacific Conference on Medical and Biological Engineering（第七届亚太地区生物工程学术会议）论文集 >Preparation of nanoparticle of methoxy poly(ethylene glycol)/ poly(ε-caprolactone)/ methoxy poly(ethylene glycol) triblock copolymer for drug delivery applications
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Preparation of nanoparticle of methoxy poly(ethylene glycol)/ poly(ε-caprolactone)/ methoxy poly(ethylene glycol) triblock copolymer for drug delivery applications

机译：甲氧基聚乙二醇/聚ε-己内酯/甲氧基聚乙二醇三嵌段共聚物纳米颗粒的制备

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摘要

Triblock copolymers of monomethoxy poly (ethylene glycol) (mPEG,Mw= 5000) and poly(ε-caprolactone) (PCL) were prepared with different length of PCL compositions.Initially diblock copolymer of mPEG-PCL was synthesized by ring opening polymerization of mPEG with ε-caprolactone with SnOct as catalyst.The diblock copolymer was reacted with carboxylic acid terminated mPEG via coupling reaction.The amphiphilic block copolymers were based on hydrophobic (PCL) segments and two hydrophilic (PEG) segments.The structures of ring opening polymerization and triblock copolymer were characterized by 1H NMR and FT-IR spectroscopy.These copolymers can self-assembly into nanoscopic micelles.The size and size population distribution of micelles were also determined by dynamic light scattering (DLS).The nanoparticle sizes are around 16-30 nm.The cytotoxicity of copolymeric nanoparticles was investigated against mouse fibroblast cells lines (L929).
机译：制备了具有不同长度PCL的单甲氧基聚乙二醇（mPEG，Mw = 5000）和聚（ε-己内酯）（PCL）的三嵌段共聚物。最初通过mPEG的开环聚合反应合成mPEG-PCL的二嵌段共聚物。 ε-己内酯和SnOct为催化剂，二嵌段共聚物通过偶联反应与羧酸封端的mPEG反应，两亲嵌段共聚物以疏水（PCL）链段和两个亲水（PEG）链段为基础，开环聚合的结构和通过1H NMR和FT-IR光谱对三嵌段共聚物进行表征，这些共聚物可以自组装成纳米胶束，并通过动态光散射（DLS）确定胶束的尺寸和尺寸分布，纳米颗粒尺寸约为16-30。纳米纳米粒子对小鼠成纤维细胞系（L929）的细胞毒性进行了研究。

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