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首页> 外文会议>International Conference on Smart Materials - Smart/Intelligent Materials and Nanotechnology >Preparation and Drug Release Studies of Chitosan/Methoxy Poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery
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Preparation and Drug Release Studies of Chitosan/Methoxy Poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery

机译：壳聚糖/甲氧基聚（乙二醇）-B-聚（D，L-丙交酯 - 共乙醇酰基）纳米复合材料用作控释药物递送的制备和药物释放研究

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摘要

Nanocomposite chitosan-based films incorporated with drug-loaded methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) nanoparticles were prepared by forming drug-loaded nanoparticles in chitosan solution before suspension-solution film casting. Salicylic acid was used as a poorly-water soluble model drug. The nanocomposite films with DLL/G ratios of 100/0 and 85/15 mol% and chitosan/diblock copolymer/drug ratios of 80/1/1, 80/2/2 and 80/4/4 (w/w) were prepared and investigated. The sizes of drug-loaded nanoparticles into the chitosan films were approximate or less than 100 nm. Nanopores were observed in the resulted chitosan films incorporated with drug-loaded nanoparticles when the diblock copolymer ratio was increased up to 2. Number and size of the nanopores increased as increasing the diblock copolymer ratio. Only the nanocomposite films with chitosan/diblock copolymer/drug ratio of 80/1/1 (w/w) showed slower drug release than the chitosan film.
机译：通过形成药物负载的纳米颗粒制备纳入药物甲氧基聚（乙二醇）-B-聚（D，L-丙交酯 - 共乙酰基）二嵌段共聚物（MPEG-B-PDLLG）纳米颗粒的基于纳米复合壳聚糖的薄膜。壳聚糖溶液在悬浮液薄膜铸造前。水杨酸用作水溶性差的模型药物。具有100/0和85/15摩尔％和壳聚糖/二嵌段共聚物/药物比例为80/1/1,80 / 2/2和80/4/4（w / w）的纳米复合薄膜准备和调查。将药物纳米颗粒的尺寸近似或小于100nm。当二嵌段共聚物比增加至2.纳米孔的数量和尺寸随着增加二嵌段共聚物比而增加时，在加入药物纳米粒子的所得壳聚糖膜中观察到纳米孔。仅具有壳聚糖/二嵌段共聚物/药物比例的纳米复合膜为80/1/1（w / w）显示出比壳聚糖薄膜的较慢的药物释放。

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