A COMPUTATIONAL MODEL OF DIRECT INFUSION INTO THE RAT BRAIN: CORPUS CALLOSUM AND HIPPOCAMPUS

机译：直接注入大鼠脑的计算模型：US体和海马

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Despite the high therapeutic potential of many macromolecular drugs, it has proven difficult to apply them to treatment of cancer and other degenerative diseases of the central nervous system (CNS) due to low capillary permeability and low diffusivity. To overcome these barriers, recent experimental studies have shown local infusion, i.e., convection-enhanced delivery (CED), to be a promising delivery technique in the brain and spinal cord [1-3]. Predictive models of extracellular fluid flow and transport during CED would be useful for treatment optimization and planning.

机译：尽管许多大分子药物具有很高的治疗潜力，但由于毛细血管通透性低和扩散性低，已证明难以将它们用于治疗癌症和中枢神经系统（CNS）的其他退行性疾病。为了克服这些障碍，最近的实验研究表明局部输注，即对流增强递送（CED），是在脑和脊髓中有希望的递送技术[1-3]。 CED期间细胞外液流动和运输的预测模型将对治疗优化和规划很有用。

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《ASME summer bioengineering conference;SBC2009》|2009年|P.1263-1264|共2页
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Jung Hwan Kim; Garrett W. Astary; Thomas H. Mareci; Malisa Sarntinoranont;
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中图分类人体工程学;
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1. A voxelized model of direct infusion into the corpus callosum and hippocampus of the rat brain: model development and parameter analysis [J] . Jung Hwan Kim, Thomas H. Mareci, Malisa Sarntinoranont Medical and Biological Engineering and Computing . 2010,第3期

机译：直接注入大鼠大脑call体和海马体的体素化模型：模型开发和参数分析
2. A voxelized model of direct infusion into the corpus callosum and hippocampus of the rat brain: model development and parameter analysis. [J] . Kim JH, Mareci TH, Sarntinoranont M Medical and Biological Engineering and Computing: Journal of the International Federation for Medical and Biological Engineering . 2010,第3期

机译：直接注入大鼠大脑call体和海马体的体素化模型：模型开发和参数分析。
3. Gross morphology and morphometric sequelae in the hippocampus, fornix, and corpus callosum of patients with severe non-missile traumatic brain injury without macroscopically detectable lesions: a T1 weighted MRI study. [J] . Tomaiuolo F, Carlesimo GA, Di Paola M, Journal of Neurology, Neurosurgery and Psychiatry . 2004,第9期

机译：严重非导弹性颅脑损伤但无肉眼可见病变的患者海马，穹ni和call体的总体形态和形态后遗症：T1加权MRI研究。
4. Image-based detection of Corpus Callosum variability for more accurate discrimination between autistic and normal brains [C] . Elnakib A., El-Baz A., Casanova M.F., 17th IEEE International Conference on Image Processing . 2010

机译：基于图像的Corpus Callosum变异性检测，可以更准确地区分自闭症和正常大脑
5. Drug infusion control: An extended direct model reference adaptive control strategy. [D] . Romanillos Palerm, Cesar Carlos. 2003

机译：药物输注控制：扩展的直接模型参考自适应控制策略。
6. A voxelized model of direct infusion into the corpus callosum and hippocampus of the rat brain: model development and parameter analysis [O] . Jung Hwan Kim, Thomas H. Mareci, Malisa Sarntinoranont -1

机译：将肠道胼um胼call软骨和大鼠海马直接输注的体蛋白化模型：模型开发和参数分析
7. Comparative studies on the growth of the corpus callosum. I. On the area of the corpus callosum, measured on the sagittal section of the albino rat brain [O] . Nobuharu Suitsu 1920

机译：语料库胼um的比较研究。 I.在Corpus胼callosum的区域上，测量在白化大鼠大脑的矢状部分
8. Second Generation Flexible Computing Environment for Computational Modeling of Brain Function and Neuroimaging Data Analysis [R] . Cohen, J. D. 2010

机译：第二代灵活计算环境，用于脑功能和神经影像数据分析的计算建模

A COMPUTATIONAL MODEL OF DIRECT INFUSION INTO THE RAT BRAIN: CORPUS CALLOSUM AND HIPPOCAMPUS

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