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首页> 外文会议>ASME summer bioengineering conference;SBC2008 >HYALURONIC ACID MACROMER CONCENTRATION INFLUENCES FUNCTIONAL MSC CHONDROGENESIS IN PHOTOCROSSLINKED MSC-LADEN HYDROGELS
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HYALURONIC ACID MACROMER CONCENTRATION INFLUENCES FUNCTIONAL MSC CHONDROGENESIS IN PHOTOCROSSLINKED MSC-LADEN HYDROGELS

机译：光交联的MSC负载水合物中的透明质酸宏观浓度对功能性MSC软骨生成的影响

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摘要

Intrinsic repair of articular cartilage is poor, and so numerous tissue engineering strategies have been developed for producing functional cartilage replacements. Photopolymerizable mcthacrylated hyaluronic acid (MeHA) hydrogels have been developed as a potential hydrogel that possesses the distinct advantage of being biologically relevant as well as easily modified to generate a range of hydrogel properties, To date, optimization of this hydrogel has been carried out by adjusting macromer molecular weight, concentration, and extent of methacrylation. Recent studies using McHA hydrogels with auricular chondrocytes have shown that adjustments in these parameters can have significant impact on cell viability and construct maturation.
机译：关节软骨的内在修复能力很差，因此已经开发出许多组织工程策略来生产功能性软骨替代物。已开发出可光聚合的甲基丙烯酸丙烯酸透明质酸（MeHA）水凝胶，它具有潜在的水凝胶特性，具有与生物相关的独特优势，并且易于修饰以产生一系列水凝胶特性。大分子单体的分子量，浓度和甲基丙烯酸化程度。使用McHA水凝胶和耳软骨细胞进行的最新研究表明，这些参数的调整可能对细胞活力和构建成熟度产生重大影响。

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