The feasibility of using PWI analysis software in assessment of carbogen breathing BOLD-fMRI in normal prostate

机译：使用PWI分析软件评估正常前列腺中碳素呼吸BOLD-fMRI的可行性

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Objective To investigate the feasibility of using PWI analysis software in assessment of carbogen breathing BOLD-fMRI in normal prostate. Materials and Methods BOLD-fMRI was performed using a 1.5 Tesla superconducting magnetic scanner (Siemens) equipped with a pelvic phased-array multi-coil in 15 healthy volunteers. BOLD (T2*-weighted EPI sequence, 13 slices, 3mm thickness) were acquired during 5×2minute episodes alternating between room air and carbogen (95%O2/5%CO2) breathing. All data were transferred to Siemens Leonardo Workstation and different regions of interests (ROI) of central zone (CZ) and peripheral zone (PZ) were drawn by a radiologist. All of the data was transferred to GE Advanced Workstation 4.2. The indexes of PWI were calculated by Functool 2 which included signal intensity-time curve (SI-TC), positive enhancement integral (PEI), mean time to enhance (MTE), time to minimum (TTP), maximum slope of decrease (MSD) and maximum slope of Iecrease (MSI). The indexes of and were analyzed with Independent-samples t-test. Results The mean value of PEI, MTE, TTP, MSI and MSD in CZ were 13.89±6.74, 703.32±251.38 ms, 220.05±81.86 ms, 56.53±24.12 and 59.48±23.16 respectively. The mean value of PEI, MTE, TTP, MSI and MSD in PZ were 8.73±5.20, 700.95±252.84 ms, 201.41±88.37ms, 60.09±21.97 and 64.47±25.77. The PEI, TTP and MTE of CZ were higher than those of PZ (P<0.05), while the MSD of CZ were lower than that of PZ (P<0.05). Conclusion The indexes of PWI can be used in assessment of carbogen breathing BOLD in normal prostate.

机译：目的探讨采用PWI分析软件在正常前列腺术中呼吸大胆的评估中的可行性。使用15个健康志愿者，使用配备有1.5特斯拉超导磁扫描仪（Siemens）进行大胆-FMRI进行大胆的FMRI。在室内空气和碳化物（95％O 2/5％CO 2）呼吸期间，在5×2mutute发作期间获得了大胆（T2 * -weighted EPI序列，13片，3mm厚度）。将所有数据转移到西门子Leonardo工作站和中央区（CZ）和外周区（PZ）的不同兴趣区域（ROI）被放射科医师。所有数据都被转移到GE高级工作站4.2。 PWI的索引由CuScTool 2计算，其中包含信号强度时间曲线（Si-Tc），正增强积分（PEI），平均增强（MTE），时间为最小（TTP），减少最大斜率（MSD ）和IECrease的最大斜率（MSI）。用独立样品T检验分析和分析的指标。结果CZ中PEI，MTE，TTP，MSI和MSD的平均值为13.89±6.74,703.32±251.38ms，分别为220.05±81.86ms，56.53±24.12和59.48±23.16。 PEI，MTE，TTP，MSI和MSD中PZ的平均值为8.73±5.20,700.95±252.84ms，201.41±88.37ms，60.09±21.97和64.47±25.77。 CZ的PEI，TTP和MTE高于PZ（P <0.05），而CZ的MSD低于PZ的MSD（P <0.05）。结论PWI的指标可用于评估正常前列腺症的颅底呼吸大胆。

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《2010 3rd International Conference on Biomedical Engineering and Informatics》|2010年|613-616|共4页
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Wang Xi-Zhen; Dong Peng; Sun Ye-Quan; Wang Bin; Liu Jin-Gang; Jiao Zi-Mei;
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中图分类放射医学基础理论;
关键词
BODL-fMRI; magnetic resonance imaging; perfusion weighted imaging; prostate;

机译：BODL-fMRI;磁共振成像;灌注加权成像;前列腺;

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2. Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans [J] . R Alonzi, A R Padhani, R J Maxwell, British Journal of Cancer . 2009,第4期

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4. The feasibility of using PWI analysis software in assessment of carbogen breathing BOLD-fMRI in normal prostate [C] . Wang Xi-Zhen, Dong Peng, Sun Ye-Quan, 2010 3rd International Conference on Biomedical Engineering and Informatics . 2010

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5. Analysis of hedgehog-responding cells in normal prostate stroma and in prostate cancer. [D] . Levine, Charles M. 2009

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6. Blood oxygenation level-dependent magnetic resonance imaging during carbogen breathing: differentiation between prostate cancer and benign prostate hyperplasia and correlation with vessel maturity [O] . Ningning Di, Ning Mao, Wenna Cheng, 2016

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The feasibility of using PWI analysis software in assessment of carbogen breathing BOLD-fMRI in normal prostate

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