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首页> 外文会议>2011 IEEE International Conference on Automation Science and Engineering >Preclinically assessed optimal control of postprandial glucose excursions for type 1 patients with diabetes
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Preclinically assessed optimal control of postprandial glucose excursions for type 1 patients with diabetes

机译：临床前评估的1型糖尿病患者餐后血糖波动的最佳控制

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Type 1 Patients with Diabetes (Type 1 PwDs) have to frequently adjust their insulin dosage to keep their Blood Glucose concentration (BG) within normal bounds. Meal intakes represent the most important disturbance that has to be accounted for. Its effect differs for every individual as well as for every meal. These specificities are automatically taken into account in the approach proposed in this paper. Model parameters are identified for every couple (Patient, Meal) of interest and optimal control is applied to generate individualized meal specific insulin profiles. The method does not require the use of a continuous BG meter, the profiles being infused in an open-loop manner. Results from a preliminary clinical study are presented. The concept is shown to be effective, despite limitations due to the aggressive execution chosen. Improvements are proposed and a possible practical implementation is described.
机译：1型糖尿病患者（1型PwDs）必须经常调整其胰岛素剂量，以使其血糖浓度（BG）保持在正常范围内。进餐是必须考虑的最重要的干扰。它的效果对于每个人以及每顿饭都是不同的。本文提出的方法会自动考虑这些特殊性。为感兴趣的每对夫妇（患者，膳食）确定模型参数，并应用最佳控制来生成个性化的膳食特异性胰岛素谱。该方法不需要使用连续的BG测量仪，轮廓以开环方式注入。给出了初步临床研究的结果。尽管由于选择了激进的执行方式而受到限制，但该概念仍然有效。提出了改进并描述了可能的实际实现。

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