目的：探讨空腹C肽（C0）、餐后2 hC肽（C2）与空腹C肽比值（C2/C0）与初诊2型糖尿病患者血糖波动的关系。方法选取2012年4月—2014年3月于泰州市第三人民医院内分泌科住院治疗的初诊2型糖尿病患者54例为研究对象。患者入院后测定C0、食用标准100 g馒头餐后2 hC肽（ C2）水平，佩戴动态葡萄糖监测系统进行动态血糖监测72 h，记录日间平均血糖（ MBG）、日间平均血糖波动幅度（ MAGE）、血糖标准差（ SDBG）、最大血糖波动幅度（ LAGE）。分别比较C0≥1.1μg/L和<1.1μg/L、C2/C0≥3.0和<3.0患者上述指标水平的差异。结果 C0<1.1μg/L患者MBG、MAGE、SDBG、LAGE高于C0≥1.1μg/L患者，差异有统计学意义（ P<0.05）。C2/C0<3.0患者MBG、MAGE、SDBG、LAGE高于C2/C0≥3.0患者，差异有统计学意义（ P<0.05）。结论 C0及C2/C0均能影响初诊2型糖尿病患者血糖波动，C0<1.1μg/L和C2/C0<3.0的患者血糖波动较大。%Objective To investigate the effects of fasting C -peptide( C0 )and the ratio of C2/C0 on the blood glucose fluctuation in newly diagnosed type 2 diabetic patients. Methods We enrolled 54 newly diagnosed type 2 diabetic patients who were admitted into the Department of Endocrinology of the Third People's Hospital of Taizhou in Jiangsu Province from April 2012 to March 2014. The C0 ,C2 after 100 g steamed bun intake,72 h dynamic blood glucose monitor by wearing dynamic blood glucose monitoring system,MBG,MAGE,SDBG and LAGE of the patients were tested. The above indicators were compared between the patients with C0≥1. 1 μg/L and patients with C0 <1. 1 μg/L and between patients with C2/C0≥3. 0 and patients with C2/C0 <3. 0. Results The patients with C0 <1. 1 μg/L were significantly higher(P <0. 05)than the patients with C0≥1. 1 μg/L in MBG,MAGE,SDBG and LAGE. The patients with C2/C0 <3. 0 were significantly higher( P<0. 05)than the patients with C2/C0≥3. 0 in MBG,MAGE,SDBG and LAGE. Conclusion Fasting C-peptide and the ratio of C2/C0 both have influence on blood glucose fluctuations in newly diagnosed type 2 diabetic patients. Patients with C0 <1. 1μg/L and C2/C0 <3. 0 have greater fluctution in blood glucose.
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