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首页> 美国卫生研究院文献>Journal of Diabetes Investigation >Analysis of factors influencing postprandial C‐peptide levels in Japanese patients with type 2 diabetes: Comparison with C‐peptide levels after glucagon load
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Analysis of factors influencing postprandial C‐peptide levels in Japanese patients with type 2 diabetes: Comparison with C‐peptide levels after glucagon load

机译：日本2型糖尿病患者餐后C肽水平的影响因素分析：与胰高血糖素负荷后C肽水平的比较

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>Aims/Introduction:  Postprandial serum C‐peptide levels are readily determined in clinical practice and have a good correlation with serum C‐peptide levels after glucagon load; the measurement is often used as an index of endogenous insulin secretion. However, the factors affecting postprandial serum C‐peptide levels remain to be evaluated.>Materials and Methods:  To investigate the clinical factors affecting postprandial serum C‐peptide, 2‐h postprandial C‐peptide levels after breakfast (PPCPR) were analyzed retrospectively for comparison with glucagon‐stimulated C‐peptide (CPR‐6min) levels measured during hospital admission in 273 Japanese patients with type 2 diabetes.>Results:  Multiple regression analysis showed that years from diagnosis, body mass index (BMI) and HbA1c were the major independent variables predicting PPCPR (R2 = 0.315). HbA1c was a major factor predicting PPCPR, but did not predict CPR‐6min. In addition, HbA1c was negatively correlated with PPCPR (r = −0.410, P < 0.0001) and PPCPR/CPR‐6min (r = −0.313, P < 0.0001).>Conclusions:  PPCPR was correlated with common factors predicting CPR, including years from diagnosis and BMI, but also was negatively correlated with HbA1c, a unique factor. These results show that chronic elevation of the glucose level might impair endogenous insulin secretion after meal load, but might have little effect on endogenous insulin secretion after glucagon load. >(J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00126.x, 2011)
机译：>目标/简介：餐后血清C肽水平在临床实践中很容易确定，并且与胰高血糖素负荷后的血清C肽水平有很好的相关性；该测量通常用作内源性胰岛素分泌的指标。但是，影响餐后血清C肽水平的因素仍有待评估。>材料和方法：研究影响早餐后餐后2 h餐后血清C肽水平的临床因素（回顾性分析了PPCPR）与273名日本2型糖尿病患者住院期间胰高血糖素刺激的C肽（CPR-6min）水平的比较。>结果：多元回归分析表明，从诊断起算，体重指数（BMI）和HbA1c是预测PPCPR的主要独立变量（R 2 = 0.315）。 HbA1c是预测PPCPR的主要因素，但并未预测CPR-6min。此外，HbA1c与PPCPR呈负相关（r = −0.410，P <0.0001）和PPCPR / CPR-6min（r = −0.313，P <0.0001）。>结论： PPCPR与常见预测心肺复苏的因素，包括从诊断到BMI的年限，还与独特的因素HbA1c呈负相关。这些结果表明，进餐后葡萄糖水平的长期升高可能会损害内源性胰岛素的分泌，而对胰高血糖素后的内源性胰岛素分泌的影响可能很小。 >（《糖尿病研究》杂志，doi：10.1111 / j.2040-1124.2011.00126.x，2011年）

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