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Effective Epidemic Control via Strategic Vaccine Deployment: A Systematic Approach

机译:通过战略性疫苗部署有效控制流行病:一种系统方法

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Vaccination is an effective way to control infectious disease spreading and epidemic by adjusting the composite structure of susceptible, infectious and vaccinated populations. There are three factors related to vaccine deployment arrangements; they are: (1) total amount of vaccine. (2) vaccine releasing time, and (3) vaccine distribution method. Yet the impact of these factors still remains to be systematically understood. In our study, we further develop a modified compartmental model that incorporates five age-grouped populations and a survey-based contact matrix. We study this model with current H.1N1 influenza parameters. The developed infection equations for each age community enable us to simulate both within- and between-group epidemic transmission dynamics. By simulating the infection dynamics under different vaccine deployment schedules, we discuss the impact of deployment factors on epidemic spreading dynamics.
机译:疫苗接种是通过调整易感人群,感染人群和接种人群的复合结构来控制传染病传播和流行的有效途径。与疫苗部署安排有关的三个因素;它们是:(1)疫苗总量。 (2)疫苗发布时间,以及(3)疫苗分配方法。这些因素的影响仍然有待系统地理解。在我们的研究中,我们进一步开发了一个改良的隔间模型,该模型包含了五个年龄分组的人口和一个基于调查的联系矩阵。我们用当前的H.1N1流感参数研究该模型。为每个年龄群体开发的感染方程使我们能够模拟群体内和群体间的流行传播动态。通过模拟不同疫苗部署时间表下的感染动态,我们讨论了部署因素对流行传播动态的影响。

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