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首页> 外文会议>International Symposium on Information Technologies in Medicine and Education;ITME 2012 >NF-κB and p38 MAPK: Major regulators in skeletal muscle development
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NF-κB and p38 MAPK: Major regulators in skeletal muscle development

机译：NF-κB和p38 MAPK：骨骼肌发育的主要调节因子

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Nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (p38 MAPK) are intimately related to skeletal muscle abnormalities. Since that, an interest has been found to investigate their functions in skeletal muscle development. Skeletal muscle development is a very complicated process involving cell differentiation, apoptosis, protein synthesis and degradation. Previous studies indicated that NF-κB acted as dule roles in skeletal muscle differentiation, by contrast, p38 MAPK is a clear regulator in promoting this process. Recently, an intriguing field of investigating the cross talk between NF-κB and p38 MAPK is emerging, and to further complete the picture between NF-κB and p38 MAPK will be filled with prospect. So, the most recent reports on this aspect are included in this paper.
机译：核因子κB（NF-κB）和p38丝裂原活化蛋白激酶（p38 MAPK）与骨骼肌异常密切相关。从那以后，已经发现有兴趣研究其在骨骼肌发育中的功能。骨骼肌发育是一个非常复杂的过程，涉及细胞分化，凋亡，蛋白质合成和降解。先前的研究表明，NF-κB在骨骼肌分化中起着双重作用，相反，p38 MAPK是促进这一过程的明确调节剂。近来，研究NF-κB与p38 MAPK之间的串扰的有趣领域正在出现，并且为进一步完善NF-κB与p38 MAPK之间的图片将充满前景。因此，本文包含了有关此方面的最新报告。

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