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Surface Plasmon Resonance enhanced Common Path Interferometry for high sensitivity label free biomolecule interaction analysis

机译：表面等离子体共振增强的常见路径干涉测量高灵敏度标记无生物分子相互作用分析

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A biomolecule interaction detection system using common path interferometry enhanced by surface plasmon resonance has been developed that provides multiplexed label free detection of biomolecule analytes at unprecedented sensitivities. Differential phase analysis of two orthogonally polarized components of a single laser beam gives interferometric measurement of refractive index changes at a biosensor surface. Surface plasmon resonance enhances the phase differential to give ultimate sensitivity below 5×10{sup}(-8) RIU. Discreet two dimensional area analyses within the laser beam allow simultaneous interrogations of multiple analytes in a microarray format by using diode array detectors optically aligned with elements on the transducer. Preliminary results establish current sensitivity and dynamic range, and demonstrate detection of proteins and whole organisms such as bacteria. Differential signal acquisition from a multi-diode array with specifically functionalized transducers demonstrates multiplexed microarray analysis.
机译：已经开发了使用表面等离子体共振增强的使用公共路径干涉测量法的生物分子相互作用检测系统，其提供了在前所未有的敏感性下的生物分子分析物的多路复用标记。单个激光束的两个正交偏振分量的差异相位分析使得生物传​​感器表面的折射率变化的干涉测量。表面等离子体共振增强了相位差异，使最终敏感性低于5×10 {sup}（ - 8）Riu。激光束内的谨慎二维区域分析允许通过使用与换能器上的元件光学对准的二极管阵列检测器以微阵列格式同时询问多个分析物。初步结果建立电流敏感性和动态范围，并证明蛋白质和整个生物如细菌的检测。具有特定功能化换能器的多二极管阵列的差分信号采集演示了多路复用的微阵列分析。

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