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首页> 外文会议>ASME summer bioengineering conference;SBC2012 >EFFECTS OF TISSUE DEHYDRATION ON OPTICAL DIFFUSE REFLECTANCE AND TRANSMITTANCE IN EX VIVO PORCINE SKIN
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EFFECTS OF TISSUE DEHYDRATION ON OPTICAL DIFFUSE REFLECTANCE AND TRANSMITTANCE IN EX VIVO PORCINE SKIN

机译：组织脱水对离体猪皮肤光学扩散反射和透射的影响

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摘要

Soft tissues are heterogeneous materials that may be considered mixtures of water, proteins, and cells. The high degree of mismatch in refractive index between these constituents causes tissues to be highly turbid media [1]. Mechanical optical clearing is a technique for reducing tissue scattering and improving light-based diagnostics and therapeutics. Mechanical optical clearing is performed using indentation to locally modify tissue optical response, and this effect has been shown to be reversible in vivo [2]. This effect is attributed to transient changes in tissue water distribution as a result of interstitial pore flow of water due to tissue compression. This leads to the hypothesis that tissue optical response is also correlated to the tissue's state of hydration. The goal of this study was to investigate whether or not a difference in tissue water content produces a measurable difference in tissue optical response and to correlate that response with mechanical deformation. Both diffuse reflectance and transmittance were selected as extrinsic optical signals of interest.
机译：软组织是异质材料，可以认为是水，蛋白质和细胞的混合物。这些成分之间的折射率高度失配导致组织成为高度混浊的介质[1]。机械光学清除是一种用于减少组织散射并改善基于光的诊断和治疗的技术。使用压痕进行机械光学清除可以局部改变组织的光学反应，这种作用在体内是可逆的[2]。该作用归因于由于组织压缩而导致的水的孔隙孔隙流动导致组织水分布的瞬时变化。这导致了这样的假设，即组织的光学反应也与组织的水合作用状态相关。这项研究的目的是调查组织含水量的差异是否会在组织光学响应中产生可测量的差异，并将该响应与机械变形相关联。选择漫反射率和透射率作为感兴趣的非本征光学信号。

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