HEALTHY VS DISEASED TRANSPORT AND MIXING IN THE HUMAN LEFT VENTRICLE

机译：健康与人类左脑室的疾病运输和混合

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It has become increasingly clear that the dynamics of the left ventricle (LV) plays a major role in dictating overall cardiac health. Phase-contrast magnetic resonance imaging (PCMRI) and Doppler-ultrasound echocardiography can measure flow characteristics inside the human left ventricle in vivo, including diagnostic data useful for evaluating pathological conditions such as cardiomyopathies. Studying these flow patterns is a potential avenue for heart failure diagnosis. Traditional studies based on Eulerian measures computed from instantaneous velocity data, e.g. streamlines, vorticity, Q-criterion, etc., can be insufficient or unreliable to fully understand unsteady blood flow behavior. We used the Finite-Time Lyapunov Exponent (FTLE) approach to compute Lagrangian coherent structures (LCS) to gain insight into how blood is transported inside the LV. LCS can be thought of as special moving boundaries in the flow that partition regions with different dynamics, and whose coordinated motion organizes transport and mixing.

机译：越来越清楚的是，左心室（LV）的动力学在决定整体心脏健康方面起着重要作用。相衬磁共振成像（PCMRI）和多普勒超声超声心动图可以测量体内人左心室内的血流特征，包括可用于评估病理状况（例如心肌病）的诊断数据。研究这些流动模式是心力衰竭诊断的潜在途径。基于欧拉测度的传统研究是根据瞬时速度数据计算得出的，例如流线，涡度，Q准则等可能不足或不可靠，无法完全理解不稳定的血流行为。我们使用有限时间Lyapunov指数（FTLE）方法来计算拉格朗日相干结构（LCS），以深入了解血液如何在LV内运输。 LCS可以看作是流动中的特殊运动边界，它以不同的动力学划分区域，并且其协调的运动组织了运输和混合。

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《ASME summer bioengineering conference;SBC2012》|2012年|81-82|共2页
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Sahar Hendabadi; Juan C. del Alamo; Shawn C. Shadden;
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1. Intraobserver reliability of two-dimensional ultrasound derived strain imaging in the assessment of the left ventricle, right ventricle, and left atrium of healthy human hearts [J] . OxboroughD., GeorgeK., BirchK.M. Echocardiography. . 2012,第7期

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2. Comparison of gene expression between left atria and left ventricles from non-diseased humans [J] . Masako Tsubakihara, Neal K. Williams, Anne Keogh, Proteomics . 2004,第1期

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4. HEALTHY VS DISEASED TRANSPORT AND MIXING IN THE HUMAN LEFT VENTRICLE [C] . Sahar Hendabadi, Juan C. del Alamo, Shawn C. Shadden ASME bioengineering conference . 2012

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HEALTHY VS DISEASED TRANSPORT AND MIXING IN THE HUMAN LEFT VENTRICLE

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