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首页> 外文会议>IEEE International Ultrasonics Symposium >An ex-vivo setup for characterization of atherosclerotic plaque using shear wave elastography and micro-computed tomography
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An ex-vivo setup for characterization of atherosclerotic plaque using shear wave elastography and micro-computed tomography

机译：用于使用剪切波弹性造影和微型计算机断层扫描表征动脉粥样硬化斑块的EX-VIVO设置

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Quantification of the mechanical properties of atherosclerotic plaque has shown to be important in assessing carotid artery plaque vulnerability. For such, shear wave elastography (SWE) has been applied on both in-vitro and in-vivo setups. The aim of this study was to build an ex-vivo setup for combined evaluation of plaque characteristics using SWE and micro-computed tomography (μCT). As a proof-of-concept of the constructed experimental setup, a single human carotid plaque specimen was extracted during carotid endarterectomy. The plaque was imaged in the μCT system, and subsequently imaged using SWE. For the SWE measurement, group and phase velocity was extracted from the obtained in-phase/quadrature data, with its spatial distribution being compared to anatomical features visible in the μCT images. The results indicated wave velocity changes at boundaries identified in the μCT, with group velocity data slightly increasing when entering a calcified nodule. Additionally, μCT images seemed to provide good contrast between several plaque constituens using the defined imaging settings. Overall, the study represents a proof-of-concept for detailed ex-vivo plaque analysis using combined SWE and μCT, with obtained wave speed and shear modulus values falling within observed values for atherosclerotic plaque tissue. With an experimental setup defined, future studies on carotid plaque behaviour both in SWE and μCT is enabled, where a large-scale plaque study could be performed to investigate the ability of SWE to differentiate between different plaque types.
机译：动脉粥样硬化斑块的机械性能的定量表明在评估颈动脉斑块脆弱性方面是重要的。对于这样的，已经在体外和体内设置上施加了剪切波弹性造影（SWE）。本研究的目的是建立一个Ex-Vivo设置，用于使用SWE和微计算机断层扫描（μCT）对斑块特性的组合评估。作为构建实验设置的概念验证，在颈动脉胚胎切除术期间提取单个人颈动脉斑块标本。斑块在μCT系统中成像，随后使用SWE成像。对于SWE测量，从获得的同相/正交数据中提取组和相速度，其空间分布与μCT图像中可见的解剖特征进行比较。结果指示在μCT中识别的边界的波速改变，当进入钙化结节时，群体速度数据略有增加。另外，μCT图像似乎在使用定义的成像设置之间提供若干斑块成分之间的良好对比度。总的来说，该研究代表了使用组合SWE和μCT的详细的前体噬斑分析的概念证据，其中波速和剪切模量值落入观察到的动脉粥样硬化斑块组织的值。通过定义实验设置，使SWE和μCT中的颈动脉斑块行为的未来研究能够进行，其中可以进行大规模的斑块研究以研究SWE在不同斑块类型之间区分的能力。

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