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首页> 外文会议>World Congress on Medical Physics and Biomedical Engineering >CHANGES IN LUNG PERFUSION DISTRIBUTION DUE TO RADIATION IN LUNG CANCER PATIENTS TREATED WITH 3D CONFORMAL RADIATION THERAPY AND STEREOTACTIC BODY RADIATION THERAPY
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CHANGES IN LUNG PERFUSION DISTRIBUTION DUE TO RADIATION IN LUNG CANCER PATIENTS TREATED WITH 3D CONFORMAL RADIATION THERAPY AND STEREOTACTIC BODY RADIATION THERAPY

机译：3D保形放射治疗和定性体放射治疗对肺癌患者放射致肺灌注分布的变化

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Purpose: To compare correlations between radiation and perfusion damage in lung cancer patients treated with 3D conformal radiation therapy (CRT) (both radical and palliative intent) and stereotactic body radiation therapy (SBRT). Materials/Methods: Thirteen non-small cell lung cancer patients receiving radiation therapy were included in this study. Eight of them were treated using 3D-CRT with palliative or radical intent (prescription doses 30~43Gy and 50~63Gy respectively, conventional fractionation). Five patients were treated with SBRT (prescription dose is 48Gy to the edge of the PTV in 4 fractions). Perfusion single-photon emission tomography (SPECT) scans using 99mTc were performed before RT and 2-3 months after RT. These scans were used to assess the change in lung perfusion, i.e. blood flow, as an effect of radiation on the normal lung during RT. Dose and corresponding percentage reduction in the SPECT intensity were used to establish dose-response curves (DRC). Results: Large inter-patient variation in dose-response of lung perfusion was found in all three groups. Reperfusion was common, especially in patients treated with palliative CRT. Meaningful DRC for perfusion change after RT cannot be established in this group. Meanwhile the dose-response in radical CRT and SBRT groups was pronounced and DRC were consistent. DRC from these two groups indicates about 1% reduction in lung perfusion per Gy in total dose delivered to the lung, irrespective of dose per fraction.
机译：目的：比较肺癌患者辐射和灌注损伤的相关性，治疗3D全成形放射治疗（CRT）（CRT）（综合性术语）和立体定向体放射治疗（SBRT）。材料/方法：本研究纳入13例接受放射治疗的非小细胞肺癌患者。其中八个使用3D-CRT进行姑息或自由基意图（处方剂量30〜43Gy和50〜63gy，常规分馏）。用SBRT治疗五名患者（处方剂量为48Gy，在4分级分中PTV的边缘）。使用99MTC的灌注单光子发射断层扫描（SPECT）扫描在RT和RT 2-3个月之前进行。这些扫描用于评估肺灌注的变化，即血液流动，作为辐射在RT期间正常肺的影响。 SPECT强度的剂量和相应的百分比降低建立剂量 - 反应曲线（DRC）。结果：在所有三组中发现了肺灌注剂量响应的大型患者互连变异。再灌注是常见的，特别是在用姑息治疗的患者中患者。在该组中无法建立RT后的灌注变化的有意义的DRC。同时，激进CRT和SBRT组中的剂量反应显着，DRC一致。来自这两组的DRC表明每GY的肺灌注量减少约1％，其量为肺的总剂量，无论每馏分多少剂量为剂量。

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