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首页> 外文会议>World Congress on Medical Physics and Biomedical Engineering >Respiratory parameters have different patterns in imposed-inspiration and imposed-expiration within a closed pneumatic circuit in rats
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Respiratory parameters have different patterns in imposed-inspiration and imposed-expiration within a closed pneumatic circuit in rats

机译：呼吸参数在大鼠闭合的气动回路内具有不同的模式。在大鼠的闭合气动回路内具有不同的模式

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Computer-controlled research ventilators for small animals (SAV) are often used to assess the respiratory mechanics' parameters such as resistance and elastance of the respiratory system in animal models of disease. In commercially available SAVs, it is common to obtain such parameters with the forced oscillation of a given volume of air into respiratory system with a quasi-sinusoidal pattern in a closed pneumatic circuit (i.e. both the injection and the removal of gas during the piston movement). We hypothesized that obtaining the respiratory mechanical parameters with the linear single-compartment model (LSCM) during the forced inspiration and forced expiration (when calculated together) is not sufficient to explain the physiology of the respiratory system exposed to high doses of bronchial agonist. In order to verify this, male Wistar rats (n = 5) were anesthetized, orotracheally intubated, mechanically ventilated at 90bpm (or 1.5Hz) with a tidal volume of lOmL/kg, and a positive end-expiratory pressure (PEEP) was set at 3cmH20. The ventilation was performed in a commercial mechanical ventilator (flexiVent, SCIREQ Inc., Canada) and the animals were infused with a saline solution (PBS), followed by 3 increasing doses (3, 30 and 300mg/mL) of the bronchial agonist methacholine (MCh). Respiratory parameters were calculated by the LSCM. Pressure and volume data, calibrated and corrected by a proprietary software, were analyzed using a computational routine. The full quasi-sinusoidal signal data was compared to inlet and outlet of air from the lungs separately. The data obtained showed that the difference among the three signals (i.e. whole signal, imposed-inspiration, and imposed-expiration) is pronounced at the higher dose (MCh 300mg/mL). Data from imposed-inspiration alone seem to better reflect the respiratory mechanics when a large dose of bronchial agonist is used.
机译：小型动物（SAV）的计算机控制的研究呼吸机通常用于评估呼吸力学的疾病呼吸系统抗性和弹性的参数。在市售的节省中，通常可以获得具有在闭合气动回路中的准正弦图案的给定体积的空气量的强制振荡的这些参数（即在活塞运动期间喷射和移除气体的呼吸系统）。我们假设在强制启动和强制呼气期间用线性单隔室模型（LSCM）获得呼吸机械参数（当计算出时）不足以解释暴露于高剂量的支气管激动剂的呼吸系统的生理学。为了验证这一点，雄性Wistar大鼠（n = 5）被麻醉，在90bpm（或1.5hz）用loml / kg的潮气体积机械通风，设定阳性呼气压力（窥视）在3cmh20。在商用机械呼吸机（Flexivent，Scireq Inc.，Canada）中进行通风，并且将动物注入盐水溶液（PBS），然后用3增加的剂量（3,30和300mg / ml）的支气管激动剂甲素（MCH）。通过LSCM计算呼吸参数。使用计算程序分析通过专有软件进行校准和校正的压力和体积数据。将完整的准正弦信号数据与来自肺部的空气的入口和出口进行比较。所获得的数据表明，在较高剂量（MCH 300mg / ml）上发音为三个信号（即整个信号，施加的启动和施加到期）之间的差异。仅当使用大剂量的支气管激动剂时，单独施加激励的数据似乎更好地反映了呼吸力学。

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