Application of laser speckle contrast image in the evaluation of arthritis animal model

机译：激光散斑对比图像在关节炎动物模型评价中的应用

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Arthritis is a chronic inflammatory disease that induces potentially damaging and commonly disabling. Various imaging modalities have been used for the evaluation of arthritis. This study aimed to investigate the feasibility of laser speckle contrast image (LSCI) in the evaluation of the severity and early stage of arthritis in animal model. Arthritis was induced on mouse foot and evaluated by a trained expert and the LSCI. The arthritis severity was quantitatively evaluated by speckle index (SI) computed from LSCI. In visual inspection by an expert, it was difficult to evaluate the arthritis because there was no noticeable different between control mouse group (CMG) and arthritis mouse group (AMG) in erythema. However, arthritis was easily evaluated by significant SI different between the CMG and AMG. In addition, the LSCI also successfully evaluated the early stage of arthritis, presenting different SI distribution depending on lesion.

机译：关节炎是一种慢性炎症疾病，诱导潜在的损伤和通常禁用。各种成像方式已被用于关节炎的评估。本研究旨在调查激光散斑对比图像（LSCI）在动物模型中关节炎严重程度和早期阶段的可行性。关节炎在小鼠脚上诱导并由训练有素的专家和LSCI评估。通过从LSCI计算的斑点指数（SI）定量评估关节炎严重程度。在专家的目视检查中，难以评估关节炎，因为在红斑的对照小鼠组（CMG）和关节炎小鼠组（AMG）之间没有明显不同。然而，通过CMG和AMG之间的显着Si易评估关节炎。此外，LSCI还成功地评估了关节炎的早期阶段，根据病变提出不同的Si分布。

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《Conference on photonic therapeutics and diagnostics IX》|2013年|85650Q.1-85650Q.7|共7页
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Taeyoon Son; Won Hyuk Jang; Jihoon Park; Hyung-Ju Yoon; Jeon Lee; Wan-Uk Kim; Byungjo Jung;
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4. Application of laser speckle contrast image in the evaluation of arthritis animal model [C] . Taeyoon Son, Won Hyuk Jang, Jihoon Park, Conference on photonic therapeutics and diagnostics IX . 2013

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Application of laser speckle contrast image in the evaluation of arthritis animal model

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