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首页> 外文会议>IEEE Nuclear Science Symposium and Medical Imaging Conference >The Effect of Non-rigid Misregistration in Sequential Quantitative SPECT for Targeted Radionuclide Therapy- a Simulation Study
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The Effect of Non-rigid Misregistration in Sequential Quantitative SPECT for Targeted Radionuclide Therapy- a Simulation Study

机译：非刚性误解在序序定量SPECT中的疗效对靶向放射性核素治疗的影响 - 一种模拟研究

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Non-rigid organ misregistration is an important problem for patients undergoing sequential quantitative SPECT for 3D dosimetry for targeted radionuclide therapy (TRT) treatment planning. This study aims to evaluate effects of these misregistrations on the accuracy of 3D dosimetry. We used 3 anatomical variations and 3 respective In-Ill Zevalin distributions of the digital 4D Extended Cardiac Torso (XCAT) phantom to model the deformation in different organs such as liver, kidneys, spleen and stomach. We simulated SPECT scans acquired at 5 time points, i.e., 1, 12, 24, 72 and 144 hrs post-injection of 111In Zevalin. Organs with uniform activity concentrations were randomly translated and rotated within 5 pixels/degrees, while the change of the total volume of each organ was within 5 % except for the stomach. The 24-hr scan served as a reference. An analytical projector modeling attenuation, scatter and the geometric collimator-detector-response of a medium energy collimator was used to generate noisy projections representing a realistic count level for 128 views over 360°. Reconstructed images were obtained using OS-EM with attenuation, scatter and geometric collimator-detector-response compensation. Voxel-by-voxel integration over different time points followed by convolution with a ~(90)Y dose kernel was used to generate 3D dose distribution images. For each phantom, we compared the organ dose and its dose volume histogram (DVH) for (i) no organ deformation and (ii) organs with deformation. The mean difference of organ doses between two sets of images were 3.88%, -6.73%, -7.32% and -14.42% for lung, liver, kidneys and spleen respectively. However, even for the organs with dose errors <5%, the associated normalized absolute errors in DVH were >10%. We conclude that organ misregistration and deformation are important factors in limiting accuracy of 3D dosimetric quantities and whole body non-rigid registration of sequential quantitative SPECT is essential for accurate TRT treatment planning.
机译：非刚性器官失准是经历了3D剂量进行有针对性的放射性核素治疗（TRT）治疗计划连续定量SPECT患者的一个重要问题。这项研究旨在评估在3D剂量的准确性这些对齐不准的影响。我们使用3种解剖变异和数字4D扩展心脏躯干（XCAT）幻象的3各自在III族的Zevalin分布在不同的器官，如肝，肾，脾和胃变形进行建模。我们模拟SPECT扫描在5个时间点获取的，铟 - 111泽娃灵的即后喷射1，12，24，72和144个小时。具有均匀浓度的活性器官，随机翻译和5个像素/度之内旋转，而每个器官的总体积的变化在5％以内除胃。 24小时扫描充当参照。分析投影建模衰减，散射和几何一个中等能量准直仪的准直器 - 检测器响应被用来产生表示为128个享有360°的现实计数水平嘈杂突起。使用OS-EM与衰减，散射和几何准直器 - 检测器，响应补偿获得重建图像。体素逐体素积分而不同的时间点，随后用〜（90）Y剂量内核卷积被用来产生3D剂量分布图像。对于每一个幻象，我们比较了器官剂量和用于（ⅰ）没有器官变形和（ii）与变形器官其剂量体积直方图（DVH）。两组图像之间器官剂量的平均差异为3.88％，-6.73％，-7.32％和肺，肝，肾-14.42％和脾。然而，即使对于与剂量误差<5％，在DVH相关联的归一化绝对误差均> 10％的器官。我们的结论是器官失准和变形是限制3D剂量学量的准确度和连续定量SPECT全身非刚性配准是准确的TRT治疗计划必不可少的重要因素。

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