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首页> 外文会议>ASME bioengineering conference >AN AUTOMATED SIMULATION PROTOCOL FOR EXERCISE PHYSIOLOGY IN FONTAN PATIENTS USING A CLOSED-LOOP LUMPED-PARAMETER MODEL
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AN AUTOMATED SIMULATION PROTOCOL FOR EXERCISE PHYSIOLOGY IN FONTAN PATIENTS USING A CLOSED-LOOP LUMPED-PARAMETER MODEL

机译：基于闭环集总模型模型的丰坦病患者运动生理学自动模拟协议

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摘要

Single ventricle physiology is one of the most severe forms of congenital heart disease in which an infant is born with only one functional pumping chamber. These patients must go through a series of surgical procedures concluding with the Fontan procedure, which connects the superior and inferior vena cavae to the pulmonary arteries, bypassing the right side of the heart entirely. Reduced exercise capacity is a common morbidity in Fontan patients, leading to decreased quality of life, and the etiology of lowered exercise performance remains unclear. Exercise conditions place high demands on the cardiovascular system; any good surgical design must consider the behavior of the system at stress. Invasive clinical measurements during exercise pose many challenges and are typically not standard of care. There is a need to better understand Fontan exercise physiology and to predict clinical outcomes using computational tools.
机译：单心室生理是先天性心脏病的最严重形式之一，其中婴儿出生时只有一个功能性的泵房。这些患者必须经过一系列的外科手术程序，包括丰坦手术，该手术将上腔静脉和下腔静脉连接到肺动脉，完全绕开了心脏的右侧。运动能力下降是丰坦患者的常见病，导致生活质量下降，运动能力下降的病因尚不清楚。运动条件对心血管系统有很高的要求;任何好的外科手术设计都必须考虑系统在压力下的行为。运动过程中的有创临床测量带来许多挑战，通常不是护理的标准。需要更好地了解方丹运动生理学并使用计算工具预测临床结果。

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