首页> 外文会议>ASME bioengineering conference >EXPRESSION OF PRIMARY CILIA ON LIVER STEM AND PROGENITOR CELLS: POTENTIAL ROLE FOR MECHANOSENSING IN LIVER DEVELOPMENT
【24h】

EXPRESSION OF PRIMARY CILIA ON LIVER STEM AND PROGENITOR CELLS: POTENTIAL ROLE FOR MECHANOSENSING IN LIVER DEVELOPMENT

机译:原发性唾液在肝干和祖细胞中的表达:在肝发育中机制调控的潜在作用

获取原文

摘要

The primary cilium is a non-motile organelle that projects out from the plasma membrane of many cell types in the body. It consists of an axoneme with microtubules arranged in a 9+0 arrangement that extends from the mother centriole contained within the basal body. Once thought to be a non-essential organelle, it is now known that primary cilia have an important role in embryonic and post-natal development, as well as maintenance of adult tissues. Mutations affecting primary ciliary development result in a class of serious diseases known as ciliopathies. Recent research suggests that the primary cilia/ centrosomes might play a role in embryonic stem cell differentiation through cell cycle regulation and their association with the Hedgehog signaling pathway.
机译:初级纤毛是一种非运动性细胞器,从体内许多细胞类型的质膜伸出。它由带有微管的轴突素组成,微管以9 + 0的形式排列,从包含在基体内的母中心开始延伸。曾经被认为是非必需的细胞器,现在知道原发纤毛在胚胎和出生后发育以及维持成人组织中具有重要作用。影响初级睫状体发育的突变会导致一类称为纤毛病的严重疾病。最近的研究表明,初级纤毛/中心体可能通过细胞周期调控及其与Hedgehog信号通路的关联在胚胎干细胞分化中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号