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Application of SAW gas chromatography in the early screening of lung cancer

机译：SAW气相色谱法在肺癌早期筛查中的应用

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Lung cancer is the leading cause of cancer death in China and the whole world. Early diagnosis is key to reduce the mortality from lung cancer. Exhaled breath analysis can be used in the early screening of lung cancer. Many scientists in the world have carried out the research and nominated dozens of volatile organic compounds as biomarkers for lung cancer. But the results from different researchers were not consistent, because the human body odor is affected by eating habits, environment and numerous other factors, resulting in large variation, and the sample sizes were not large enough (maximum 285). In order to increase the sample size, a rapid analysis method is necessary. SAW gas chromatography can be used to realize the wide spectrum (volatile and semi volatile organic compounds), fast (few minutes) and high sensitivity (ppb~ppt) analysis. Using airbags sampling, direct injection mode, we have gotten several volatile organic compounds reported in the literature by GC/SAW analysis of the exhaled breath samples of 19 lung cancer patients and 19 healthy volunteers.
机译：肺癌是中国乃至全世界癌症死亡的主要原因。早期诊断是降低肺癌死亡率的关键。呼气分析可用于肺癌的早期筛查。世界上许多科学家进行了这项研究，并提名了数十种挥发性有机化合物作为肺癌的生物标志物。但是，来自不同研究人员的结果并不一致，因为人的气味受饮食习惯，环境和许多其他因素的影响，从而导致差异很大，并且样本量不够大（最多285个）。为了增加样本量，需要一种快速分析方法。 SAW气相色谱可用于实现宽光谱（挥发性和半挥发性有机化合物），快速（几分钟）和高灵敏度（ppb〜ppt）分析。使用安全气囊采样，直接注射模式，通过对19位肺癌患者和19位健康志愿者的呼出气样品进行GC / SAW分析，我们获得了文献中报道的几种挥发性有机化合物。

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