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首页> 外文会议>IET International Conference on Biomedical Image and Signal Processing >Damage to the dorsal attention network and interactions with the control and sensory-motor networks in late-onset depression
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Damage to the dorsal attention network and interactions with the control and sensory-motor networks in late-onset depression

机译：迟发性抑郁症中对背侧注意网络的损害以及与控制和感觉运动网络的相互作用

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Late-onset depression (LOD) is considered as a disconnection syndrome that disrupts brain networks subserving multidomain cognitive and behavioural functions. Interactions between resting-state networks (RSNs) are considered to be important for cognitive control. The present study is to perform resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to delineate the connectivity patterns of intra- and inter-network in LOD and to examine the altered functional interactions between RSNs. A total of 28 LOD patients and 40 matched healthy controls (HC) were recruited. We investigated rs-fcMRI in the cognitive control network (CON), the dorsal attention network (DAN), and the sensory-motor network (SMN). For intra-network, compared with HC, LOD showed significantly reduced connectivity strengths within DAN, CON, and SMN. For inter-network, compared with HC, LOD exhibited significantly reduced connections in DAN-CON pair and DAN-SMN pair while no difference was found in the CON-SMN pair. The present study provides powerful and novel insights into the functional organization of RSNs, and functional interactions between RSNs in LOD. It further suggests that LOD utilizes an altered model of cognitive control where the altered DAN may mediate the transition stage of the information processing from bottom-up information about sensory-motor inputs to high-level cognition.
机译：迟发性抑郁症（LOD）被认为是一种断开综合征，破坏了服务于多域认知和行为功能的大脑网络。静止状态网络（RSN）之间的相互作用被认为对认知控制很重要。本研究将执行静止状态功能连接磁共振成像（rs-fcMRI），以描述LOD中网络内部和网络之间的连接模式，并检查RSN之间的功能交互作用是否改变。总共招募了28位LOD患者和40位匹配的健康对照（HC）。我们研究了认知控制网络（CON），背注意力网络（DAN）和感觉运动网络（SMN）中的rs-fcMRI。对于内部网络，与HC相比，LOD显示DAN，CON和SMN内的连接强度大大降低。对于网络间，与HC相比，LOD在DAN-CON对和DAN-SMN对中的连接显着减少，而在CON-SMN对中没有发现差异。本研究为RSN的功能组织以及LOD中RSN之间的功能交互提供了强大而新颖的见解。它进一步表明，LOD利用一种改变的认知控制模型，其中改变后的DAN可以介导信息处理从有关感觉运动输入的自下而上信息到高级认知的过渡阶段。

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