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A robust dual-mode MPC approach to ensuring critical quality attributes in Quality-by-Design

机译：强大的双模式MPC方法可确保按设计质量获得关键质量属性

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In the Quality-by-Design (QbD) paradigm for pharmaceutical processes, critical quality attributes (CQAs) must meet specifications for all possible realizations of critical process parameters (CPPs) within a design space. During the startup of such a process, it is desired to begin meeting CQA specifications as quickly as possible and then robustly guarantee that specifications will continue to be met. This paper proposes a robust dual-mode model predictive controller (RDMPC) for meeting these objectives, for discrete-time linear systems with a linear fractional transformation (LFT) uncertainty description. The receding-horizon controller steers the system into a controlled invariant set in finite time, after which the terminal controller is applied to robustly guarantee specifications on CQAs for all time. The proposed control algorithm is demonstrated for a continuous stirred-tank reactor.
机译：在适用于制药过程的质量 - 设计（QBD）范例中，关键质量属性（CQAS）必须满足设计空间内所有可能的关键过程参数（CPP）的规范。在此过程的启动期间，希望尽可能快地开始满足CQA规范，然后稳健地保证规范将继续满足。本文提出了一种强大的双模模型预测控制器（RDMPC），用于满足这些目标，用于具有线性分数变换（LFT）不确定性描述的离散时间线性系统。解晶控制器将系统置于有限时间内的受控不变集之后，在其中终端控制器应用于省略CQAS上的鲁棒性。所提出的控制算法用于连续搅拌罐反应器。

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