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Shannon capacity of signal transduction for multiple independent receptors

机译:香农对多种独立受体的信号转导能力

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Cyclic adenosine monophosphate (cAMP) is considered a model system for signal transduction, the mechanism by which cells exchange chemical messages. Our previous work calculated the Shannon capacity of a single cAMP receptor; however, a typical cell may have thousands of receptors operating in parallel. In this paper, we calculate the capacity of a cAMP signal transduction system with an arbitrary number of independent, indistinguishable receptors. By leveraging prior results on feedback capacity for a single receptor, we show (somewhat unexpectedly) that the capacity is achieved by an IID input distribution, and that the capacity for n receptors is n times the capacity for a single receptor.
机译:环磷酸一腺苷(cAMP)被认为是信号转导的模型系统,该信号转导是细胞交换化学信息的机制。我们之前的工作计算了单个cAMP受体的Shannon容量;然而,典型的细胞可能具有成千上万个并行运行的受体。在本文中,我们计算了具有任意数量的独立,无法区分的受体的cAMP信号转导系统的容量。通过利用先前关于单个受体的反馈能力的结果,我们表明(有点出乎意料),该能力是通过IID输入分布实现的,并且n个受体的能力是单个受体的能力的n倍。

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