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首页> 外文会议>Conference on imaging processing >Unified Registration Framework for Cumulative Dose Assessment in Cervical Cancer across External Beam Radiotherapy and Brachytherapy
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Unified Registration Framework for Cumulative Dose Assessment in Cervical Cancer across External Beam Radiotherapy and Brachytherapy

机译：宫颈癌外剂量放射疗法和近距离放射疗法累积剂量评估的统一注册框架

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Dose accumulation across External Beam Radiotherapy (EBRT) and Brachytherapy (BT) treatment fractions in cervical cancer is extremely challenging due to structural dissimilarities and large inter-fractional anatomic deformations between the EBRT and BT images. The brachytherapy applicator and the bladder balloon, present only in the BT images, introduce missing structural correspondences for the underlying registration problem. Complex anatomical deformations caused by the applicator and the balloon, different rectum and bladder filling and tumor shrinkage compound the registration difficulties. Conventional free-form registration methods struggle to handle such topological differences. In this paper, we propose a registration pipeline that first transforms the original images to their distance maps based on segmentations of critical organs and then performs non-linear registration of the distance maps. The resulting dense deformation field is then used to transform the original anatomical image. The registration accuracy is evaluated on 27 image pairs from stage 2B-4A cervical cancer patients. The algorithm reaches a Hausdorff distance of close to 0.5 mm for the uterus, 2.2 mm for the bladder and 1.7 mm for the rectum when applied to (EBRT,BT) pairs, taken at time points more than three months apart. This generalized model-free framework can be used to register any combination of EBRT and BT images as opposed to methods in the literature that are tuned for either only (BT,BT) pair, or only (EBRT,EBRT) pair or only (BT,EBRT) pair. A unified framework for 3D dose accumulation across multiple EBRT and BT fractions is proposed to facilitate adaptive personalized radiation therapy.
机译：由于结构差异以及EBRT和BT图像之间的较大的部分间解剖结构变形，宫颈癌在整个外部束放射疗法（EBRT）和近距离放射治疗（BT）治疗部位的剂量累积极具挑战性。仅在BT图像中出现的近距离放射治疗涂药器和膀胱球囊针对潜在的配准问题引入了缺失的结构对应关系。由涂药器和球囊引起的复杂的解剖变形，不同的直肠和​​膀胱充盈以及肿瘤缩小使套准困难。常规的自由格式注册方法难以处理此类拓扑差异。在本文中，我们提出了一种配准管线，该管线首先根据关键器官的分割将原始图像转换为它们的距离图，然后对距离图进行非线性配准。然后将所得的密集形变场用于转换原始解剖图像。在来自2B-4A期宫颈癌患者的27对图像上评估套准准确性。当应用于（EBRT，BT）对时，该算法的子宫Hausdorff距离接近0.5 mm，膀胱为2.2 mm，直肠为1.7 mm，在三个月以上的时间点获取。与仅针对（BT，BT）对或仅针对（EBRT，EBRT）对或仅针对（BT）调整的文献中的方法相反，该通用的无模型框架可用于注册EBRT和BT图像的任何组合，EBRT）对。提出了跨多个EBRT和BT分数的3D剂量累积的统一框架，以促进自适应个性化放射治疗。

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