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Biological and experimental factors affecting the assessment of cervical softening during pregnancy with shear wave elasticity imaging

机译：剪切波弹性成像影响评估妊娠期宫颈软化的生物学和实验因素

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Spontaneous preterm birth, the foremost source of neonatal mortality, could potentially be prevented by objectively detecting abnormal changes in the uterine cervix. Shear Wave Elasticity Imaging (SWEI) biomarkers can quantify cervical softening that precedes vaginal delivery. This task can be complicated by biological (i.e., heterogeneity of cervical stiffness and pregnancy history) and experimental confounders (i.e., posture during scanning). Here we investigate how these confounders influence shear wave speed (SWS) as an objective biomarker of cervical softening during pregnancy. We apply SWEI longitudinally in pregnant Rhesus macaques and compare SWS estimates from supine transabdominal (TA) and prone inter-cavitary (IC) approaches.
机译：自发性早产是新生儿死亡的最主要来源，可以通过客观地检测子宫子宫颈的异常变化来预防。剪切波弹性成像（SWEI）生物标记物可以量化阴道分娩前的宫颈软化。生物学（即子宫颈僵硬和怀孕史的异质性）和实验混杂因素（即扫描过程中的姿势）可能会使这项任务变得复杂。在这里，我们调查这些混杂因素如何影响剪切波速度（SWS），作为妊娠期间宫颈软化的客观生物标志物。我们将SWEI纵向应用于怀孕的恒河猴，并比较仰卧经腹（TA）和俯卧腔间（IC）方法的SWS估计值。

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