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首页> 外文会议>IEEE International Conference on Bioinformatics and Biomedicine >MCVdb: A database for knowledge discovery in Merkel cell polyomavirus with applications in T cell immunology and vaccinology
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MCVdb: A database for knowledge discovery in Merkel cell polyomavirus with applications in T cell immunology and vaccinology

机译：MCVdb：一个用于在默克尔细胞多瘤病毒中发现知识的数据库，并在T细胞免疫学和疫苗学中有应用

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Merkel Cell Polyomavirus (MCV) is associated with more than 80% of Merkel cell carcinoma (MCC), a rare but highly lethal form of skin cancer. We made use of the immunological data on MCV available through publications and databases and constructed MCV T cell Antigen Database (MCVdb). MCVdb contains 734 curated antigen entries of MCV antigenic proteins and 30 experimentally verified T cell epitopes. The data were subject to extensive quality control (redundancy elimination, error detection, and vocabulary consolidation). A set of computational tools for in-depth analysis, such as sequence comparison using BLAST search, multiple alignments of antigens, and T cell epitope conservation analysis have been integrated within the MCVdb. Predicted Class I and Class II HLA-binding peptides for 15 common HLA alleles are included in this database as putative targets. MCVdb is a unique data source providing a comprehensive list of MCV antigens and peptides. MCVdb is publicly available at http://projects.met-hilab.org/mcv/.
机译：默克尔细胞多瘤病毒（MCV）与80％以上的默克尔细胞癌（MCC）相关，后者是一种罕见但致命的皮肤癌。我们利用可通过出版物和数据库获得的MCV免疫学数据，并构建了MCV T细胞抗原数据库（MCVdb）。 MCVdb包含734个经过整理的MCV抗原蛋白抗原条目和30个经过实验验证的T细胞表位。数据受到广泛的质量控制（冗余消除，错误检测和词汇合并）。 MCVdb中集成了一组用于深入分析的计算工具，例如使用BLAST搜索的序列比较，抗原的多重比对以及T细胞表位保守性分析。该数据库中包含15种常见HLA等位基因的预测I类和II类HLA结合肽，作为推定目标。 MCVdb是一个独特的数据源，提供了MCV抗原和肽的完整列表。 MCVdb可在http://projects.met-hilab.org/mcv/上公开获得。

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