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Impedance-based detection of Schistosoma mansoni larvae viability for drug screening

机译：基于阻抗的曼氏血吸虫幼虫活力检测以进行药物筛选

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Human schistosomiasis is a neglected tropical disease caused by trematodes, affecting almost 250 million people worldwide. For the past 30 years, treatment has relied on the large-scale administration of praziquantel. However, concerns regarding the appearance of drug-resistance parasites require efforts in identifying novel classes of suitable drugs against schistosomiasis. The current drug screening system is manual, slow and subjective. We present here a microfluidic platform capable of detecting changes in viability of Schistosoma mansoni larvae (Newly Transformed Schistosomula, NTS). This platform could serve as a pre-screening tool for the identification of drug candidates. It is composed of a pair of coplanar electrodes integrated in a microfluidic channel for the detection and quantification of NTS motility. Comparison of viability detection by using our platform with the standard visual evaluation shows that our method is able to reliably detect viable and non-viable NTS at high sensitivity, also in case of low-motility parasites, while enabling a 10 fold decrease in sample consumption.
机译：人类血吸虫病是一种由线虫引起的被忽视的热带病，全世界有近2.5亿人受到感染。在过去的30年中，治疗一直依赖于吡喹酮的大规模给药。然而，对耐药性寄生虫的出现的关注需要努力确定新型类别的适合血吸虫病的合适药物。当前的药物筛选系统是手动的，缓慢的和主观的。我们在这里介绍了一种微流控平台，能够检测曼氏血吸虫幼虫（新近转化的血吸虫，NTS）活力的变化。该平台可作为识别候选药物的预筛选工具。它由集成在微流体通道中的一对共面电极组成，用于检测和定量NTS运动。使用我们的平台进行的活力检测与标准视觉评估的比较表明，我们的方法能够以高灵敏度可靠地检测有生命力和无生命的NTS，即使在低运动性寄生虫的情况下，也可以使样品消耗减少10倍。

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