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Development of a physical 3D anthropomorphic breast texture model using selective laser sintering rapid prototype printing

机译:使用选择性激光烧结快速原型印刷开发物理3D拟人化乳房纹理模型

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Anthropomorphic breast phantoms are useful for development and characterization of breast x-ray imaging systems. Rapid prototyping (RP) opens a new way for generating complex shapes similar to real breast tissue patterns at reasonably high resolution and a high degree of reproducibility. Such a phantom should have x-ray attenuation properties similar to adipose and fibroglandular tissue across a broad x-ray energy range. However material selection is limited to those that are compatible with the printing system, which often requires adding non-organic dopants. Fortunately, there are some off-the-shelf materials that may be suitable for breast phantoms. Here a polyamide-12/water texture phantom is being investigated, which can be used for mammography, tomosynthesis and breast CT. Polyamide-12 (PA-12) is shown to have linear attenuation coefficients across an energy range of 15 - 40 keV matching adipose tissue to within 10% effective breast density. A selective laser sintering (SLS) printer is used for manufacturing the phantom. The phantom was imaged on the Senographe Pristina (GE Healthcare, Chicago, IL), while initial assessment of 3D fidelity with the original design was performed by acquiring volume images of the phantom on a micro-CT system. A root mean distance error of 0.22 mm was seen between the micro-CT volume and the original. The PA-12 structures appeared to be slightly smaller than in the original, possibly due to infiltration of the water into the PA-12 surfaces. Power spectra measurements for mammograms of the simulated and physical phantoms both demonstrated an inverse power-law spectrum shape with exponent β= 3.72 and 3.76, respectively.
机译:拟人化的乳房体模对于乳房X射线成像系统的开发和表征非常有用。快速原型制作(RP)开辟了一种新方法,可以在合理的高分辨率和高度可重复性下生成类似于真实乳房组织图案的复杂形状。这种体模应该在宽泛的X射线能量范围内具有类似于脂肪和纤维腺组织的X射线衰减特性。但是,材料选择仅限于与打印系统兼容的材料,这通常需要添加非有机掺杂剂。幸运的是,有一些现成的材料可能适合于乳房幻像。在这里,正在研究一种聚酰胺12 /水质体模,可用于乳房X线照相,断层合成和乳腺CT。聚酰胺12(PA-12)在能量范围为15-40 keV的脂肪组织中具有线性衰减系数,使脂肪组织与乳腺有效密度相差10%以内。选择性激光烧结(SLS)打印机用于制造模型。幻像在Senographe Pristina(GE Healthcare,芝加哥,伊利诺伊州)上成像,而原始设计的3D保真度的初始评估是通过在微型CT系统上采集幻像的体像来进行的。微型CT体积与原始体积之间的根均距离误差为0.22 mm。 PA-12结构似乎比原始结构要小一些,这可能是由于水渗透到PA-12表面中造成的。模拟和物理模型的乳房X射线照片的功率谱测量均显示出幂律谱的倒数形状,分别具有指数β= 3.72和3.76。

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