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Anthropomorphic breast phantoms for evaluation of FFDM/ DBT, and breast CT using inkjet printing

机译:拟人化的乳房模型用于评估FFDM / DBT和使用喷墨打印的乳房CT

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The breast phantoms currently available for evaluating full field digital mammography (FFDM), digital breast tomosynthesis (DBT), and breast CT (bCT) systems often lack the complexity present in real breasts. In this work we present a new methodology for creating physical anthropomorphic breast phantoms for use in FFDM, DBT, and dedicated bCT systems using zinc acetate-doped ink. First, an uncompressed virtual phantom was created through analytical modeling. The model represented a breast with 28% fibroglandular density with 13 tissue classes and contained a 5 mm lesion. The breast was binarized to two tissue classes: adipose and fibroglandular tissue. The phantom was then realized through inkjet printing using dye ink doped with zinc acetate for the fibroglandular components and three candidate materials for the adipose background: parchment paper, organic paper, and office paper. The fabrication process was evaluated in terms of material realism and reproducibility using spectroscopy, a clinical FFDM system, and a benchtop bCT system. The linear attenuation coefficient of the doped ink plus parchment paper and parchment paper alone closely matched those of the fibroglandular and adipose tissues, respectively. A methodology for generating anthropomorphic breast phantoms was developed using a novel inkjet printing technique for use in FFDM/DBT, as well as dedicated breast CT systems. A novel uncompressed breast phantom for bCT was fabricated using inexpensive, easily available materials with realistic tissue properties.
机译:当前可用于评估全场数字化乳腺摄影(FFDM),数字化乳房断层合成(DBT)和乳房CT(bCT)系统的乳房模型通常缺乏真实乳房中存在的复杂性。在这项工作中,我们提出了一种新的方法,用于创建物理拟人化的人体模型,以使用醋酸锌掺杂的墨水在FFDM,DBT和专用bCT系统中使用。首先,通过分析建模创建了未压缩的虚拟体模。该模型代表的乳腺的纤维腺密度为28%,具有13种组织类别,并包含5mm的病变。乳房被二值化为两个组织类别:脂肪组织和纤维腺组织。然后通过喷墨打印实现幻影,使用掺有醋酸锌的染料墨水作为纤维状成分,为脂肪背景添加三种候选材料:羊皮纸,有机纸和办公用纸。使用光谱学,临床FFDM系统和台式bCT系统对材料的真实性和可再现性进行了评估。仅掺杂墨水加上羊皮纸和羊皮纸的线性衰减系数分别与纤毛和脂肪组织的线性衰减系数紧密匹配。使用新颖的喷墨打印技术开发了一种拟人化的乳房幻象的生成方法,该技术可用于FFDM / DBT以及专用的乳房CT系统。一种新型的未压缩的bCT人体模型是使用廉价且易于获得的具有现实组织特性的材料制成的。

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