Predicting Immune Cell Composition Using Linear Programming

机译：使用线性规划预测免疫细胞组成

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A large data set is used to infer the fraction of immune cells using gene expression data. A model should be developed to infer the fraction of immune cells from a small set of genes used in cell surface marker experiments. We present a model created by linear programming (LP) by simplex method. To evaluate the accuracy of the algorithm, we created a simulated data set and evaluated its performance against the digital cell quantization (DCQ) algorithm. Finally, we applied our LP method to the systemic lupus erythematosus (SLE) patient dataset and examined the differences from healthy controls.

机译：大数据集用于根据基因表达数据推断免疫细胞的比例。应该开发一种模型，以从用于细胞表面标志物实验的一小部分基因推断出免疫细胞的比例。我们提出了一种通过单纯形法通过线性规划（LP）创建的模型。为了评估该算法的准确性，我们创建了一个模拟数据集，并根据数字单元量化（DCQ）算法评估了其性能。最后，我们将LP方法应用于系统性红斑狼疮（SLE）患者数据集，并检查了与健康对照组的差异。

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《IEEE International Conference on Bioinformatics and Biomedicine》|2019年|2001-2004|共4页
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SeongRyeol Moon; Junbae Oh; Seungyoon Nam;
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biology computing; cellular biophysics; diseases; genetics; linear programming; molecular biophysics; patient diagnosis;

机译：生物计算;细胞生物物理学;疾病;遗传学;线性规划;分子生物物理学;患者诊断;

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1. Linear programming-based prediction of immune cell composition [J] . International journal of data mining and bioinformatics . 2020,第2期

机译：基于线性编程的免疫细胞组成预测
2. The composition of immune cells serves as a predictor of adaptive immunity in a cohort of 50-to 74-year-old adults [J] . Kennedy Richard B., Simon Whitney L., Gibson Michael J., Immunology: An Official Journal of the British Society for Immunology . 2016,第3期

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3. Predictive biomarkers for programmed death-1/programmed death ligand immune checkpoint inhibitors in nonsmall cell lung cancer [J] . Remon Jordi, Chaput Nathalie, Planchard David Current Opinion in Oncology . 2016,第2期

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4. Predicting Immune Cell Composition Using Linear Programming [C] . SeongRyeol Moon, Junbae Oh, Seungyoon Nam IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：使用线性规划预测免疫细胞组合物
5. The Role of the Wiskott-Aldrich Syndrome Protein in Regulating T Cell Programmed Cell Death Mechanisms and Implications for Autoimmunity in the Wiskott-Aldrich Syndrome. [D] . Marjanovic, Sophia Y. 2016

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6. The composition of immune cells serves as a predictor of adaptive immunity in a cohort of 50‐ to 74‐year‐old adults [O] . Richard B. Kennedy, Whitney L. Simon, Michael J. Gibson, 2016

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7. Bloodborne Cytokines for Predicting Clinical Benefits and Immune-Related Adverse Events in Advanced Non-Small Cell Lung Cancer Treated With Anti-Programmed Cell Death 1 Inhibitors [O] . Jun Oyanagi, Yasuhiro Koh, Koichi Sato, 2021

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8. Inducing Cellular Immune Responses to p53 Using Peptide and Nucleic Acid Compositions. [R] . Fikes, J., Sette, A., Sidney, J., 2005

机译：使用肽和核酸组成诱导p53的细胞免疫应答。

Predicting Immune Cell Composition Using Linear Programming

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