Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

机译：基因表达和途径生物信息学分析检测MAP3K8在甲状腺癌进展中的潜在预测价值

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Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 is up-regulated in poorly differentiated thyroid carcinomas and its expression is related to a stem cell like phenotype and a poorer prognosis and survival. Taken together these data unravel a novel mechanism for thyroid cancer progression and chemo-resistance and confirm previous results obtained in cultured thyroid cancer stem cells.

机译：甲状腺癌是最常见的内分泌恶性肿瘤。 BRAF丝氨酸/苏氨酸激酶中的突变是甲状腺癌中最常见的遗传改变。晚期和低分化甲状腺癌的靶向治疗包括BRAF途径抑制剂。在这里，我们评估了MAP3K8表达作为甲状腺癌中对BRAF抑制产生抗性的潜在驱动因素的作用。通过分析基因表达Omnibus数据存储库，在所有甲状腺癌组织学类型中，我们发现MAP3K8在分化较差的甲状腺癌中上调，其表达与干细胞（如表型）相关，并且预后和生存率较差。这些数据加在一起揭示了甲状腺癌进展和化学耐药性的新机制，并证实了在培养的甲状腺癌干细胞中获得的先前结果。

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《IEEE International Conference on Bioinformatics and Biomedicine》|2019年|2202-2206|共5页
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Valentina Di Salvatore; Fiorenza Gianì; Giulia Russo; Marzio Pennisi; Pasqualino Malandrino; Francesco Frasca; Francesco Pappalardo;
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bioinformatics; cancer; cellular biophysics; genetics; medical computing;

机译：生物信息学;癌症;细胞生物物理学;遗传学;医学计算;

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4. Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression [C] . Valentina Di Salvatore, Fiorenza Gianì, Giulia Russo, IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：基因表达和途径生物信息学分析检测MAP3K8在甲状腺癌进展中的潜在预测值
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7. Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression [O] . Valentina Di Salvatore, Fiorenza Giani, Giulia Russo, 2019

机译：基因表达和途径生物信息学分析检测MAP3K8在甲状腺癌进展中的潜在预测值

Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

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