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A suite of SVOC exposure models - estimating parameters and illustrative results

机译：一套SVOC暴露模型-估计参数和说明性结果

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This talk will review the consensus models used to predict exposure resulting from the various product categories and the subsequent contributions to exposure, as well as illustrative results. Building on the consensus-based framework previously introduced, a detailed mechanistic description of SVOC emission, transport, partitioning, and fate is presented for different product categories and environmental compartments, integrating the knowledge and understanding that has been achieved over the past decade. Emphasis is given to those models which will serve as the basis for an international consensus. The resulting suite of mechanistic exposure models can be used to support the development of predictive relationships for the estimation of emission and transport parameters, evaluate and build confidence in rapid, high-throughput exposure estimates, and inform risk-based chemical management decisions. Additionally, important gaps in the current understanding will be identified as waypoints for further research. To illustrate the framework, several examples will be presented and discussed for each product category (small and large solid products, liquid products, and sprayed products). The importance of each exposure pathway (ingestion of dust, inhalation, dermal uptake from air, and dermal uptake by direct contact) will be ranked based on the resulting exposure for each source category and pathway. Important parameters that significantly influence human exposure to SVOCs indoors will be identified by sensitivity analysis and a consistent set of methods for measuring or estimating the model parameters will be reviewed. Finally, the effectiveness of several common control strategies, such as source removal, ventilation, vacuum cleaning, and application of air purifiers, on the exposure to SVOCs from each product emission category will be evaluated.
机译：本演讲将回顾用于预测由各种产品类别产生的接触量以及随后对接触量的贡献的共识模型，以及示例性结果。在先前介绍的基于共识的框架的基础上，针对不同的产品类别和环境部分，对SVOC的排放，运输，划分和命运进行了详细的机械描述，结合了过去十年中已获得的知识和理解。重点放在将成为国际共识基础的那些模型上。由此产生的一系列机械暴露模型可用于支持预测关系的开发，以估算排放和运输参数，评估并建立对快速，高通量暴露估计的信心，并为基于风险的化学品管理决策提供依据。此外，当前认识中的重要空白将被确定为进一步研究的切入点。为了说明该框架，将针对每种产品类别（大小固体产品，液体产品和喷涂产品）提供几个示例并进行讨论。每个暴露途径的重要性（粉尘的吸入，吸入，空气中的皮肤吸收以及直接接触引起的皮肤吸收）将根据每个来源类别和途径所产生的暴露程度进行排名。将通过敏感性分析确定对人类暴露于室内SVOC的重要影响的重要参数，并将审查用于测量或估计模型参数的一套一致方法。最后，将评估几种常见控制策略（例如源去除，通风，真空清洁和应用空气净化器）对每种产品排放类别的SVOC暴露的有效性。

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