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2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate

机译：二维磁传感器阵列，用于实时细胞跟踪和多站点检测，具有更高的鲁棒性和流速

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In this article, we present a 2D oscillator array-based magnetic sensor CMOS IC for flow cytometry. The CMOS IC packaged with a microfluidic channel eliminates the need for hydro-focusing by allowing uninhibited flow over the 2D chip surface. The chip exploits multi-site detection capability allowing simultaneously high flow rate for trace cell detection, reduced false positives, and real-time cell tracking. We demonstrate these functionalities with a $7 imes 7$ array in 65-nm CMOS with lymphoma cancer cells.

机译：在本文中，我们介绍了一种用于流式细胞术的基于2D振荡器阵列的磁传感器CMOS IC。带有微流体通道的CMOS IC通过允许在2D芯片表面上无阻碍的流动，消除了对水聚焦的需求。该芯片具有多站点检测功能，可以同时以高流速进行痕量细胞检测，减少误报和实时细胞跟踪。我们在带有淋巴瘤癌细胞的65 nm CMOS中使用$ 7 x 7的阵列演示了这些功能。

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《IEEE Custom Integrated Circuits Conference》|2019年|1-4|共4页
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Hao Tang; Suresh Venkatesh; Zhongtian Lin; Xuyang Lu; Hooman Saeidi; Gulam M. Rather; Joseph R. Bertino; Chen-Yong Lin; Mehdi Javanmard; Kaushik Sengupta;
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Oscillators; Sensor arrays; Frequency measurement; Two dimensional displays; Temperature measurement; Cancer; Correlation;

机译：振荡器;传感器阵列;频率测量;二维显示;温度测量;癌症;相关性;

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1. Nucleic Acid Delivery to Magnetically-Labeled Cells in a 2D Array and at the Luminal Surface of Cell Culture Tube and Their Detection by MRI [J] . Olga Mykhaylyk, Andreas Steingotter, Hector Perea, Journal of biomedical nanotechnology . 2009,第6期

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2. Detection and Real-Time Tracking of Moving Targets Using a Color Segmentation Algorithm Robust to Irregular Illumination Variation and a Line-Based Tracker [J] . Chi-Ho KIM, Bum-Jae YOU, Hagbae KIM IEICE Transactions on Communications . 2005,第6期

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3. Real-time 3D tracking of whales by echo-robust precise TDOA estimates with a widely-spaced hydrophone array [J] . Pascale Giraudet, Herve Glotin Applied Acoustics . 2006,第11a12期

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4. 2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate [C] . Hao Tang, Suresh Venkatesh, Zhongtian Lin, IEEE Custom Integrated Circuits Conference . 2019

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2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate

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