• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>IEEE International Conference on Imaging Systems and Techniques >Non-Invasive Discrimination of Colorectal Adenomas and Non-Neoplastic Polyps with Micro-Optical Coherence Tomography Imaging
【24h】

Non-Invasive Discrimination of Colorectal Adenomas and Non-Neoplastic Polyps with Micro-Optical Coherence Tomography Imaging

机译：微光学相干断层扫描成像技术对大肠腺瘤和非赘生性息肉的非侵入性鉴别

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As one of the most common cancers and a leading cause of worldwide cancer-related mortality, colorectal cancer (CRC) imposes a huge burden on both patients and social healthcare systems. Currently, although colonoscopy screening has been widely utilized for CRC diagnosis, the commonly adopted “resect and discard” strategy for colorectal diminutive polyps treatment in CRC diagnostic process still suffers from the risk of missing the unrecognized potential malignant lesions, like adenomatous polyps. In this study, we explore and validate the feasibility of micro-optical coherence tomography (μOCT) as an intraoperative imaging tool to perform optical biopsy in gastroenterology, and thus, to improve the diagnostic accuracy of colorectal lesions. Specifically, a lab-customized μOCT system that achieves a spatial resolution of ~2.0 μm was built first, and then, was applied to acquire both cross-sectional and 3D images of the fresh tissue samples obtained from patients with colorectal polyps or colorectal cancer and just received endoscopic therapy or laparoscopic surgery. Finally, those acquired images are compared to their corresponding HE sections for discrimination of colorectal adenomas and non-neoplastic polyps. A new diagnostic strategy has also been established to determine the diagnosis sensitivity, specificity and accuracy for using μOCT to differentiate between benign polyps and adenomas. Results show that the μOCT system is capable of clearly illustrating the cellular/sub-cellular microstructure differences between colorectal adenomas and non-neoplastic polyps with the cross-sectional and en face images. While with the new diagnostic criteria applied for all 58 cases of polyps, the diagnosis accuracy, sensitivity and specificity reach up to 94.83%, 96.88% and 92.31% with a 95% confidence interval of (85.30%−98.79%), (82.89%−99.99%) and (74.74%−98.98%), respectively. Such satisfactory results demonstrate the potential of μOCT as an intraoperative diagnostic imaging tool for endoscopists to perform “optical biopsy”, and thus, make appropriate clinical decisions in clinical practice.
机译：结直肠癌（CRC）作为最常见的癌症之一，也是导致世界范围内与癌症相关的死亡率的主要原因，它给患者和社会医疗保健系统带来了沉重的负担。目前，尽管结肠镜检查已被广泛用于CRC诊断，但在CRC诊断过程中通常采用的“切除并丢弃”结直肠小息肉治疗策略仍然存在错过腺瘤性息肉等无法识别的潜在恶性病变的风险。在这项研究中，我们探索并验证了微光学相干断层扫描（μOCT）作为术中​​成像工具在胃肠病学中进行光学活检的可行性，从而提高了大肠病变的诊断准确性。具体来说，首先建立了一个实验室定制的μOCT系统，该系统可实现〜2.0μm的空间分辨率，然后将其用于获取大肠息肉或大肠癌患者和患者的新鲜组织样本的横截面图像和3D图像。刚接受内镜治疗或腹腔镜手术。最后，将那些获取的图像与其对应的HE切片进行比较，以区分大肠腺瘤和非肿瘤性息肉。还建立了一种新的诊断策略，以确定使用μOCT区分良性息肉和腺瘤的诊断敏感性，特异性和准确性。结果表明，μOCT系统能够通过横截面图像和正面图像清楚地说明大肠腺瘤和非肿瘤性息肉之间的细胞/亚细胞微观结构差异。尽管对58例息肉采用了新的诊断标准，但诊断准确性，敏感性和特异性分别达到94.83％，96.88％和92.31％，置信区间为（85.30％−98.79％）（82.89％），为95％ -99.99％）和（74.74％-98.98％）。这样令人满意的结果证明了μOCT作为内镜医师进行术中诊断成像工具进行“光学活检”的潜力，因此可以在临床实践中做出适当的临床决策。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号