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首页> 外文会议>International Photodynamic Association World Congress;Society of Photo-Optical Instrumentation Engineers;International Photodynamic Association >Novel Strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake
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Novel Strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake

机译：通过抑制参与ALA摄取的转运蛋白来提高ALA诱导的PpIX积累特异性的新策略

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Aminolevulinic acid-based photodynamic therapy (ALA-PDT) is gaining more and more attention as a newalternative in cancer treatment, particularly the conventional chemotherapy, due to its high efficiency andextremely low side effect nature. ALA-PDT is highly tumor-specific, where it increases the accumulation ofprotoporphyrin (PpIX) in mitochondria after administration of exogenous ALA, which would triggerphototoxicity of cancer cells but not in normal cells. However, protoporphyrin (PpIX), a product of ALA inheme cycle, was recently found to accumulate in normal cells, causing unnecessary cytotoxicity tosurrounding healthy cells. This phenomenon suggests a tailor-made treatment together with ALA-PDT inattempt to increase specificity. Peptide transporter 1 (PEPT1), proton coupled amino acid 1 transporters(PAT1), taurine transporters (TauT) and GABA transporter 2 (GAT2) were known to be responsible in cellularALA uptake. Inhibitors and siRNAs of these transporters were added to study their effects on PpIXproduction. Inhibitors of highly expressed transporter(s) in normal cell but not in cancer cells would serve asa new drug to increase specificity of ALA-PDT.
机译：基于氨基纤维素的光动力治疗（ALA-PDT）正在越来越多地关注新的 癌症治疗中的替代方案，特别是常规化疗，由于其高效率和常规化学疗法 极低的副作用性质。 ALA-PDT是高度肿瘤特异性的，在那里它增加了积累 在外源ALA施用后线粒体（PPIX）的原因卟啉（ppix），将触发 癌细胞的光毒性，但不在正常细胞中。但是，原因卟啉（ppix），Ala的产物 最近发现血红素循环在正常细胞中积聚，导致不必要的细胞毒性 周围健康的细胞。这种现象表明，与ALA-PDT一起定制治疗 试图增加特异性。肽转运蛋白1（Pept1），质子偶联氨基酸1转运蛋白 （Pat1），已知牛磺酸转运蛋白（绷紧）和GABA转运蛋白2（GAT2）负责细胞 阿拉的吸收。添加这些转运蛋白的抑制剂和siRNA以研究它们对PPIX的影响 生产。正常细胞中高表达转运蛋白但不含癌细胞的抑制剂将作为 一种增加Ala-PDT的特异性的新药。

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