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首页> 外文会议>Conference on Mechanisms of Photobiomodulation Therapy;Society of Photo-Optical Instrumentation Engineers >Fluorescent light energy in wound healing: when is a photon something more?
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Fluorescent light energy in wound healing: when is a photon something more?

机译：伤口愈合中的荧光能：光子什么时候还能再存在？

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Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation,and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broadspectral range (~400-700 nm) that is delivered to the target tissue below. Results from in vivo and in vitro studies haveshown FLE modulates inflammation via down-regulation of pro-inflammatory cytokines such as IL-6 and TNF-α, andstimulates mitochondria biogenesis1.A recent study showed FLE-stimulated cells responded more potently compared to cells treated with light from an LEDlight source (“Mimicking Lamp”) designed to generate the same emission spectra and power intensity profile as FLE2.FLE-treated human dermal fibroblasts (HDF) experienced up-regulated collagen production, while a minor and nonsignificanteffect was observed for the Mimicking Lamp-treated HDFs. These results suggest that photons generated byFLE either penetrate tissue differently or are absorbed differently compared to photons from a LED light source. Photonicproperties of FLE that could impact tissue penetration or absorption may include polarity or coherency, leading to differentcellular responses.To investigate if light polarity may influence cellular responses to FLE stimulation, the present study applied linear andcircular-polarizing filters to investigate the influence of FLE’s polarity on immune parameters. The data suggest that FLEpolarity contributes to its impact on biological systems. Furthermore, the immunemodulatory impact of FLE wasinvestgated in a pilot study on a human ex vivo skin model suggesting that central myeloid immune surface markes aremodulated by FLE.
机译：荧光能（FLE）是一种独特的光生物调节形式，可以刺激愈合，减少炎症， 并减轻痛苦。该系统通过激发局部基质中的生色团而起作用，该基质发散出的FLE具有广泛的 光谱范围（〜400-700 nm），将其传递至下方的目标组织。体内和体外研究的结果 显示FLE通过下调促炎性细胞因子（例如IL-6和TNF-α）来调节炎症，并且 刺激线粒体生物发生1。 最近的一项研究表明，与用LED灯处理的细胞相比，FLE刺激的细胞反应更有效。 光源（“模拟灯”）设计为产生与FLE2相同的发射光谱和功率强度曲线。 经FLE处理的人真皮成纤维细胞（HDF）胶原蛋白产生上调，而次要且无意义 对于模仿灯处理的HDF，观察到了效果。这些结果表明，由 与来自LED光源的光子相比，FLE要么穿透组织不同，要么被吸收不同。光子学 可能影响组织渗透或吸收的FLE的特性可能包括极性或相干性，从而导致 细胞反应。 为了研究光的极性是否会影响细胞对FLE刺激的反应，本研究应用了线性和线性 圆极化滤波器，用于研究FLE极性对免疫参数的影响。数据表明FLE 极性有助于其对生物系统的影响。此外，FLE的免疫调节作用是 在一项关于人体离体皮肤模型的初步研究中进行了研究，结果表明中央髓样免疫表面标记是 由FLE调制。

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