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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >In Utero Dioxin Exposure and Age at Menarche in the Seveso Second Generation
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In Utero Dioxin Exposure and Age at Menarche in the Seveso Second Generation

机译：Seveso第二代月经初潮中子宫二恶英的暴露和年龄

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Introduction: In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant and potent endocrine disrupting compound, is associated with delayed pubertal development in animal studies. On July 10,1976, an explosion at a chemical plant near Seveso, Italy exposed nearby residents to high levels of TCDD. The Seveso Women's Health Study (SWHS), initiated in 1996, is the only study to date of TCDD's health effects in a female population with the unique benefit of individual TCDD measured in blood collected near the time of the explosion. In 2014, we enrolled SWHS offspring (those exposed in utero to TCDD) in the Seveso Second Generation study. We examined the relationship of in utero TCDD exposure with reported age at onset of menarche among SWHS daughters. Methods: Age at onset of menarche (in years) was collected by maternal or self-report at interview in 341 SWHS daughters. We defined in utero TCDD exposure as initial (1976) maternal serum TCDD level and TCDD extrapolated to pregnancy. Data were analyzed using Cox proportional hazards models. Results: At interview, 287 daughters were postmenarche, averaging 25.6 (±8.0) years of age. The mean reported age at menarche was 12.1 (±1.3) years. Overall, we found no change in risk of menarche onset with a 10-fold increase in initial maternal TCDD (Hazard Ratio (HR) = 0.91, 95% CI 0.79, 1.06) or TCDD estimated at pregnancy (HR = 0.86, 95% CI 0.72, 1.03). When we considered maternal menarche status at explosion as a potentially sensitive developmental exposure window, TCDD estimated at pregnancy (loglO) was associated with later age at menarche among daughters whose mothers were premenarche at explosion (HR = 0.71, 95% CI 0.50, 1.00) but not postmenarche at explosion (HR = 0.87, 95% CI 0.71, 1.07). Conclusions: These results suggest in utero exposure to TCDD may alter pubertal timing among daughters of women who were prepubescent at the time of the Seveso accident.
机译：简介：在子宫内暴露于2,3,7,8-四氯二苯并-对-二恶英（TCDD）（一种广泛的环境污染物和有效的内分泌干扰化合物），与动物研究中的青春期发育延迟有关。 1976年7月10日，意大利塞维索（Seveso）附近一家化工厂发生爆炸，附近的居民暴露在高浓度的TCDD中。 Seveso妇女健康研究（SWHS）于1996年启动，是迄今为止在女性人群中TCDD对健康影响的唯一研究，该研究在爆炸发生时采集的血液中检测到了单独TCDD的独特优势。 2014年，我们在Seveso第二代研究中纳入了SWHS后代（在子宫内暴露于TCDD的后代）。我们研究了SWHS女儿中初潮初潮时宫内TCDD暴露与报道的年龄之间的关系。方法：在341名SWHS女儿的访谈中，通过产妇或自我报告收集了初潮初潮的年龄（以年为单位）。我们在宫内TCDD暴露中定义为初始（1976年）母体血清TCDD水平和推断到妊娠的TCDD。使用Cox比例风险模型分析数据。结果：在访谈中，有287个女儿初潮后，平均年龄为25.6（±8.0）岁。报告的初潮年龄平均为12.1（±1.3）岁。总体而言，我们发现初次母亲初次TCDD（危险比（HR）= 0.91，95％CI 0.79，1.06）或怀孕时估计的TCDD（HR = 0.86，95％CI）增加10倍时，初潮发作的风险没有改变。 0.72、1.03）。当我们将爆炸时的母亲初潮状态视为潜在的敏感发育暴露窗口时，在母亲爆炸时初潮的女儿中，怀孕时的TCDD（log10）与月经初潮年龄相关（HR = 0.71，95％CI 0.50，1.00）。但爆炸后初潮不是（HR = 0.87，95％CI 0.71，1.07）。结论：这些结果表明，子宫内接触TCDD可能会改变Seveso事故发生前青春期妇女女儿的青春期时机。

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