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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Preliminary Study to Determine the Association between Maternal Exposure to Fine Particulate Matter (PM2.5) and Adverse Pregnancy Outcomes in Lima, Peru
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Preliminary Study to Determine the Association between Maternal Exposure to Fine Particulate Matter (PM2.5) and Adverse Pregnancy Outcomes in Lima, Peru

机译：初步研究确定秘鲁利马孕妇暴露于细颗粒物（PM2.5）与不良妊娠结局之间的关联

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Environmental exposure to fine particulate matter (PM) is associated with increased risks for respiratory and cardiovascular diseases as well as some kinds of cancer and pregnancy adverse outcomes. Among others, Lima, a mega city located in Peru, has been considered one of the most contaminated cities in Latin America with mean annual concentrations of PM2.5 ranging from 35 to 16 μg/m3 (mean value: 26 μg/m3). Besides that, there are no studies related to the effect of outdoor PM air pollution on pregnancy outcomes in Lima, Peru. The aim of this preliminary study is to determine the association between maternal exposure to PM2.5 on pregnancy outcomes in a hospital-based linkage study in the metropolitan area of Lima. This study analyzes the data corresponding to the period between January 2007 and December 2009. Newborn data were obtained through the Perinatal Information System (SIP 2000 in Spanish) from two public hospitals in Lima, Peru. Preterm birth (PTB), small for gestational age (SGA) and birth weight (BW) were considered as pregnancy outcomes. Also, records of PM2.5 during this same period were recorded. Linear and logistic regression analyses were used to predict adverse pregnancy outcomes associated with PM2.5 exposure. Data included 4,173 births. Of the three pregnancy outcomes, the exposure to higher concentrations of PM2.5 (3rd quartile) were associated with an elevated risk of preterm birth in the 1st trimester (OR 1.6$2CI95% 1.06 - 2.49), 2nd trimester (OR 1.7$1CI95% 1.13 - 2.58), and 3rd trimester (OR=1.87, 0951 % 1.27 - 2.76). To sum up, maternal exposure to PM2.5 during pregnancy increase risks for preterm births. Future studies are being carried out to expand the years of exposure according to the use of time-series analysis and the collection of current newborn data.
机译：环境中暴露于细颗粒物（PM）与呼吸系统疾病和心血管疾病以及某些癌症和妊娠不良后果的风险增加有关。其中，位于秘鲁的大城市利马被认为是拉丁美洲污染最严重的城市之一，PM2.5的年平均浓度范围为35至16微克/立方米（平均价值：26微克/立方米）。除此之外，在秘鲁的利马，尚无与室外PM空气污染对妊娠结局的影响相关的研究。这项初步研究的目的是，在利马市区的一家医院为基础的连锁研究中，确定孕妇暴露于PM2.5与妊娠结局之间的关联。本研究分析了2007年1月至2009年12月期间的数据。新生儿数据是通过围产期信息系统（西班牙语为SIP 2000）从秘鲁利马的两家公立医院获得的。早孕（PTB），胎龄（SGA）和出生体重（BW）小被认为是妊娠结局。此外，还记录了同一时期的PM2.5记录。线性和逻辑回归分析用于预测与PM2.5暴露相关的不良妊娠结局。数据包括4,173例出生。在这三个妊娠结局中，暴露于较高浓度的PM2.5（第3四分位数）与早孕期（或1.6 $ 2CI95％1.06-2.49），早孕期（OR 1.7 $ 1CI95）的早产风险升高相关。 ％1.13-2.58）和第三个三个月（OR = 1.87，0951％1.27-2.76）。综上所述，孕妇在怀孕期间接触PM2.5会增加早产的风险。根据时间序列分析的使用和当前新生儿数据的收集，正在进行进一步的研究以扩大接触的年限。

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