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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Associations of Industrial Air Pollutant Mixtures with Preterm Birth and Small for Gestational Age in Alberta, Canada
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Associations of Industrial Air Pollutant Mixtures with Preterm Birth and Small for Gestational Age in Alberta, Canada

机译：加拿大艾伯塔省工业空气污染物混合物与早产和早孕年龄的关联

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Introduction: Effects of mixtures of chemicals released to the air by industrial facilities on pregnancy outcomes have been scarcely studied. We conducted a retrospective population-based cohort study to estimate associations of spontaneous preterm birth (sPTB), induced preterm birth (iPTB) and small for gestational age (SGA) with industrial air pollutant mixtures in Alberta, Canada (2006-2012). Methods: We used data from all singletons live births (n=330,957) including maternal data on 21 related risk factors. From the Canadian National Pollutant Released Inventory, we extracted 130 chemicals released into the air by 6,279 industrial facilities. We grouped all chemicals into ten broad classes including gases (e.g., CO), particulate matter (PM), Volatile Organic Compounds (VOCs), Metals, Other-inorganics, and Other-organics. We profiled the mixtures using a novel approach based on the proportional content of the ten chemical classes in the total amounts released by each facility using cluster analysis. Proximity to the facilities emitting mixtures (10-km) from the maternal postal codes at delivery was used as a proxy of exposure. Associations of the mixtures with sPTB, iPTB and SGA were assessed by logistic regression adjusting for relevant maternal risk factors and an area-level socioeconomic status. Results: We profiled eight broad groups of mixtures. Heterogeneous mixtures (including gases, PM and different proportional participation of the other chemical classes) were common (47% of the total emissions) and increased the odds of sPTB by 36% (OR=1.36; CI :1.30-1.63). Scarce mixtures with a high content (>60%) of VOCs increased the odds of SGA by 37% (OR=1.37; CI:1.11-1.69). Mixtures with a high proportion of Metals-, Other-organics- and Other-inorganics increased the odds of iPTB by 17% (OR=1.17; 0:1.05-1.30), 17% (OR=1.17; CI:1.06-1.28) and 24% (OR=1.24; 0:1.09-1.41) respectively. Conclusion: Mixtures showed differential associations with sPTB, iPTB, and SGA.
机译：简介：很少研究工业设施释放到空气中的化学物质混合物对妊娠结局的影响。我们进行了一项基于人群的回顾性队列研究，以估计加拿大阿尔伯塔省（2006-2012）的自然早产（sPTB），诱导早产（iPTB）和小胎龄（SGA）与工业空气污染物的关联。方法：我们使用了所有单胎活产婴儿（n = 330,957）的数据，包括有关21个相关危险因素的孕产妇数据。从加拿大国家污染物排放清单中，我们提取了6279个工业设施向空气中排放的130种化学物质。我们将所有化学品分为十大类，包括气体（例如CO），颗粒物（PM），挥发性有机化合物（VOC），金属，其他无机物和其他有机物。我们使用聚类分析，根据每种设施释放的总量中十种化学类别的比例含量，使用新颖的方法对混合物进行了分析。在分娩时，离与母体邮政编码发射混合物（10公里）的设施接近，以此作为暴露的代表。通过对相关孕产妇危险因素和区域一级社会经济状况进行逻辑回归分析，对混合物与sPTB，iPTB和SGA的关联性进行了评估。结果：我们分析了八大类混合物。异质混合物（包括气体，PM和其他化学类别的不同比例参与）很常见（占总排放量的47％），使sPTB的几率增加了36％（OR = 1.36; CI：1.30-1.63）。挥发性有机化合物含量高（> 60％）的稀有混合物使SGA的几率提高了37％（OR = 1.37; CI：1.11-1.69）。金属，其他有机物和其他无机物比例高的混合物将iPTB的几率提高了17％（OR = 1.17; 0：1.05-1.30），17％（OR = 1.17; CI：1.06-1.28）和24％（OR = 1.24; 0：1.09-1.41）。结论：混合物与sPTB，iPTB和SGA存在差异关联。

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