• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Short-Term Exposure to Ambient Particulate Elements and Epigenome-Wide DNA Methylation in Older Men: The Normative Aging Study
【24h】

Short-Term Exposure to Ambient Particulate Elements and Epigenome-Wide DNA Methylation in Older Men: The Normative Aging Study

机译：老年男子短期暴露于环境微粒元素和表观基因组范围的DNA甲基化：规范性衰老研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Current research suggests that short-term exposure to ambient particulate matter is associated with global and gene-specific DNA methylation (DNAm), but little is known regarding the changes in epigenome-wide caused by particulate elements (PEs). Additionally, the potential pathways remain unknown. Objective: We evaluated whether short-term exposure to ambient PEs affects DNAm in epigenome-wide and identified potential biological pathways. Method: We collected whole blood samples from the Normative Aging Study (1999-2013) and measured epigenome-wide DNAm with the lllumina Infinium HumanMethylation450 BeadChip. Ambient PEs were measured daily at a fixed monitoring station and 7 different moving averages (from 1-day to 7-day) were considered. Linear models were used to estimate the associations between 14 elements and DNAm measured in baseline (N=774), adjusting for fine particle mass, cell type, batch effects, age, body mass index, smoking, etc. Pathway analysis was also performed to explore the potential biologic mechanisms. Results: Short-term exposure to PEs was significantly associated with epigenome-wide DNAm, especially for 2-d moving average. We observed 393 Bonferroni significant CpGs, most of them related with Aluminum, Silicon, Sulfur, and Potassium. The pathway analyses suggest that the detrimental effects might be relevant to immune response and signal transduction. We also found that there were several common genes significantly associated with Aluminum, Silicon and Sulfur, such as, Alzheimer's disease related gene Low density lipoprotein Receptor Related Protein 1; obesity-related gene Protein Tyrosine Phosphatase, Receptor Type F; and cancer related gene Lysophosphatidylcholine Acyltransferase 1. Conclusions: Ours is the first study that find short-term effects on DNAm in epigenome-wide by ambient PEs, especially elements associated with road dust, sulfate and wood burning. Our findings provide insight into potential mechanistic pathways.
机译：背景：目前的研究表明，短期暴露于环境颗粒物与总体的和基因特异性的DNA甲基化（DNAm）有关，但对于由颗粒物（PE）引起的整个表观基因组的变化知之甚少。此外，潜在的途径仍然未知。目的：我们评估了短期暴露于环境PE是否会影响表观基因组范围内的DNAm，并确定了潜在的生物学途径。方法：我们收集了标准老龄化研究（1999-2013年）的全血样品，并用lllumina Infinium HumanMethylation450 BeadChip测量了表观基因组范围的DNAm。每天在固定的监测站测量环境PE，并考虑7种不同的移动平均值（从1天到7天）。使用线性模型估算基线（N = 774）中测得的14种元素与DNAm之间的关联，调整细颗粒质量，细胞类型，批次效应，年龄，体重指数，吸烟等。探索潜在的生物学机制。结果：PE的短期暴露与表观基因组范围的DNAm显着相关，尤其是二维移动平均值。我们观察到393个Bonferroni重要CpG，其中大多数与铝，硅，硫和钾有关。通路分析表明，有害作用可能与免疫应答和信号转导有关。我们还发现，有几个与铝，硅和硫显着相关的常见基因，例如，阿尔茨海默氏病相关基因低密度脂蛋白受体相关蛋白1;低密度脂蛋白受体相关蛋白1。肥胖相关基因蛋白酪氨酸磷酸酶，F型受体;结论：我们的第一个研究发现环境PE尤其是与道路扬尘，硫酸盐和木材燃烧有关的元素对整个表观基因组的DNAm具有短期影响。我们的发现为潜在的机械途径提供了见识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号