• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Environmental Epigenetics >Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study
【2h】

Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study

机译：长期环境颗粒物暴露和血液DNA甲基化年龄：VA规范性衰老研究的发现

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age. Objective: We examined the relationship of DNAm-age with fine particulate matter (PM2.5), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic. Methods: We used validated spatiotemporal models to generate 1-year PM2.5 and BC exposure levels at the addresses of 589 older men participating in the VA Normative Aging Study with 1–3 visits between 2000 and 2011 (n = 1032 observations). Blood DNAm-age was calculated using 353 CpG sites from the Illumina HumanMethylation450 BeadChip. We estimated associations of PM2.5 and BC with DNAm-age using linear mixed effects models adjusted for age, lifestyle/environmental factors, and aging-related diseases. Results: After adjusting for covariates, a 1-μg/m3 increase in PM2.5 (95% CI: 0.30, 0.75, P < 0.0001) was significantly associated with a 0.52-year increase in DNAm-age. Adjusted BC models showed similar patterns of association (β = 3.02, 95% CI: 0.48, 5.57, P = 0.02). Only PM2.5 (β = 0.54, 95% CI: 0.24, 0.84, P = 0.0004) remained significantly associated with DNAm-age in two-particle models. Methylation levels from 20 of the 353 CpGs contributing to DNAm-age were significantly associated with PM2.5 levels in our two-particle models. Several of these CpGs mapped to genes implicated in lung pathologies including LZTFL1, PDLIM5, and ATPAF1. Conclusion: Our results support an association of long-term ambient particle levels with DNAm-age and suggest that DNAm-age is a biomarker of particle-related physiological processes.
机译：背景：已经证明环境颗粒会加剧生物衰老的程度；然而，尚无研究检查它们与DNA甲基化年龄（DNAm-age）的关系，DNAm-age是基于表观基因组的DNA甲基化的时间顺序预测因子。目的：我们研究了DNAmage与细颗粒物（PM2.5）（一种可吸入颗粒物总量的度量）和黑碳（BC）（一种来自车辆交通的颗粒度量）之间的关系。方法：我们使用经过验证的时空模型在2000年至2011年间参加VA规范性衰老研究的589名老年男性的住所中生成了1年的PM2.5和BC暴露水平，进行了1-3次随访（n = 1032观察）。使用来自Illumina HumanMethylation450 BeadChip的353 CpG位点计算血液DNA年龄。我们使用针对年龄，生活方式/环境因素和衰老相关疾病调整的线性混合效应模型，估计了PM2.5和BC与DNAm-age的关联。结果：校正协变量后，PM2.5增加1μg/ m 3 （95％CI：0.30、0.75，P <0.0001）与DNAm 0.52年的增加显着相关-年龄。调整后的BC模型显示出相似的关联模式（β= 3.02，95％CI：0.48，5.57，P = 0.02）。在两粒子模型中，只有PM2.5（β= 0.54，95％CI：0.24，0.84，P = 0.0004）仍与DNAm-age显着相关。在我们的两粒子模型中，来自353个CpG中20个的甲基化水平与DNAm-年龄有关，与PM2.5水平显着相关。这些CpG中有几个定位到涉及肺部疾病的基因，包括LZTFL1，PDLIM5和ATPAF1。结论：我们的结果支持长期环境颗粒水平与DNAm-age的关联，并表明DNAm-age是颗粒相关生理过程的生物标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号