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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Contrasting Associations between Exposure to Environmental Marine Pollutants and Reports of Immune System Disorders in Greenlandic Children
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Contrasting Associations between Exposure to Environmental Marine Pollutants and Reports of Immune System Disorders in Greenlandic Children

机译：格陵兰儿童的环境海洋污染物暴露与免疫系统疾病报告之间的相互联系

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Background: Early-life exposures to environmental contaminants may modulate the development of immune system. Objective: To examine the associations between exposure to marine pollutants and prevalence of atopic diseases, antibodies and IgE concentrations. Methods: We examined 367 Greenlandic children aged 7 to 12 years from the IVAAQ and INUENDO pregnancy cohorts. Concurrent concentrations of Polychlorinated biphenyls (PCBs), Mercury (Hg), Hexachlorobenzene (HCB), B-hexachlorocyclohexane (3-HCH), and perfluoroalkyl substances (PFASs) were measured in children's blood. Diagnoses of asthma, allergy, eczema, rash, and hayfever were ascertained based on the standardized International Study of Asthma and Allergies in Childhood. We also measured Diphtheria and Tetanus antibodies and IgE concentrations in children's blood. We used generalized mixed effects models to estimate the associations between chemical concentrations and allergic diseases and antibodies concentrations. Results: Prevalence of asthma, allergy, eczema, rash, and hay fever was 14%, 13%, 14%, 17%, and 4%, respectively. We found positive associations between higher concentrations of HCB (Odds Ratios [OR] for a two-fold increase = 1.43; 95% Confidence Interval [CI]: 1.03, 1.98), Perfluorononanoic Acid (PFNA) (OR = 1.62; 95% CI: 1.01, 2.60), and Perfluorodecanoic Acid (PFDA) (OR = 1.33; 95% CI: 0.99,1.81) and asthma prevalence. In contrast, we found negative associations between HCB, PFASs, and Hg, and prevalence of eczema. For instance, a two-fold increase in PFOS and PFOA concentrations was associated with 0.40 (95% CI: 0.24, 0.65) and 0.31 (95% CI: 0.14, 0.67) lower odds of eczema. Similar negative associations were observed for the prevalence of rash. No pattern of associations was found with IgE and antibodies concentrations. Conclusions: Despite the contrasting observed associations, these findings provide further evidence on the potential immunomodulatory effects of marine pollutants.
机译：背景：生命早期暴露于环境污染物中可能会调节免疫系统的发育。目的：探讨暴露于海洋污染物中与特应性疾病，抗体和IgE浓度的患病率之间的关系。方法：我们检查了来自IVAAQ和INUENDO妊娠队列的367名7至12岁的格陵兰儿童。测量了儿童血液中多氯联苯（PCBs），汞（Hg），六氯苯（HCB），B-六氯环己烷（3-HCH）和全氟烷基物质（PFASs）的同时浓度。根据对儿童哮喘和过敏的标准化国际研究确定了哮喘，过敏，湿疹，皮疹和花粉症的诊断。我们还测量了儿童血液中的白喉和破伤风抗体和IgE浓度。我们使用广义的混合效应模型来估计化学物质浓度与过敏性疾病和抗体浓度之间的关联。结果：哮喘，过敏，湿疹，皮疹和花粉症的患病率分别为14％，13％，14％，17％和4％。我们发现较高浓度的HCB（两倍的奇数比[OR] = 1.43; 95％的置信区间[CI]：1.03、1.98），全氟壬酸（PFNA）（OR = 1.62; 95％CI）之间存在正相关关系：1.01、2.60）和全氟癸酸（PFDA）（OR = 1.33; 95％CI：0.99,1.81）和哮喘患病率。相反，我们发现HCB，PFAS和Hg与湿疹患病率之间呈负相关。例如，全氟辛烷磺酸和全氟辛烷磺酸浓度的两倍增加与湿疹几率降低0.40（95％CI：0.24，0.65）和0.31（95％CI：0.14，0.67）有关。皮疹的发生率也观察到类似的负相关性。未发现与IgE和抗体浓度相关的模式。结论：尽管观察到的协会之间存在对比，但这些发现为海洋污染物的潜在免疫调节作用提供了进一步的证据。

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